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首页> 外文期刊>Genes, brain, and behavior >Functional neuroimaging of genetic variation in serotonergic neurotransmission.
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Functional neuroimaging of genetic variation in serotonergic neurotransmission.

机译：血清素能神经传递中遗传变异的功能性神经影像学。

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Serotonin (5-hydroxytryptamine; 5-HT) is a potent modulator of the physiology and behavior involved in generating appropriate responses to environmental cues such as danger or threat. Furthermore, genetic variation in 5-HT subsystem genes can impact upon several dimensions of emotional behavior including neuroticism and psychopathology, but especially anxiety traits. Recently, functional neuroimaging has provided a dramatic illustration of how a promoter polymorphism in the human 5-HT transporter (5-HTT) gene, which has been weakly related to these behaviors, is strongly related to the engagement of neural systems, namely the amygdala, subserving emotional processes. In this commentary, we discuss how functional neuroimaging can be used to characterize the effects of polymorphisms in 5-HT subsystem genes on the response of neural circuits underlying the generation and regulation of mood and temperament as well as susceptibility to affective illness. We argue that in time, such knowledge will allow us to not only transcend phenomenological diagnosis and represent mechanisms of disease, but also identify at-risk individuals and biological pathways for the development of new treatments.
机译：5-羟色胺（5-羟色胺; 5-HT）是一种有效的生理和行为调节剂，可参与对危险或威胁等环境线索的适当反应。此外，5-HT子系统基因的遗传变异会影响情绪行为的多个方面，包括神经质和心理病理，尤其是焦虑性状。最近，功能性神经影像学已提供了一个戏剧性的例证，说明与这些行为弱相关的人5-HT转运蛋白（5-HTT）基因中的启动子多态性与神经系统即杏仁核的参与密切相关。 ，维持情感过程。在这篇评论中，我们讨论了如何使用功能性神经影像来表征5-HT子系统基因中的多态性对情绪和气质的生成和调节以及对情感性疾病的敏感性所基于的神经回路的反应。我们认为，随着时间的流逝，这些知识将使我们不仅能够超越现象学诊断并代表疾病的机制，而且还能确定处于危险中的个体和开发新疗法的生物学途径。

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