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首页> 外文期刊>Bulletin of the Korean Chemical Society >Synthesis and Peptide-binding Properties of C3-symmetric Metallomacrocycles
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Synthesis and Peptide-binding Properties of C3-symmetric Metallomacrocycles

机译：C3对称金属大环化合物的合成及其肽结合性质

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摘要

The last decade has witnessed an explosion in the field of molecular recognition. Since the pioneering work of Pederson, Cram and Lehn, many molecular receptors capable of interacting selectively with various substrates have been described. To construct such receptors, chemists use the multi-step synthetic methodology to make macro-cyclic structures that have the shape and functionalities complement to those of a given substrate. However, the macrocyclization reactions required much synthetic effort and the general applicability of these reactions still is limited because these are good for certain types of substrates only. Recently, an alternative method in which a metallo-macrocyclic receptor self-assembles from a flexible ligand by exploiting metal-ligand coordinate bond is recognized as an efficient method to construct molecular receptors.
机译：过去十年见证了分子识别领域的爆炸式增长。自从Pederson，Cram和Lehn的开创性工作以来，已经描述了许多能够与各种底物选择性相互作用的分子受体。为了构建这样的受体，化学家使用多步合成方法来制造具有与给定底物的形状和功能互补的大环结构。然而，大环化反应需要大量的合成努力，并且这些反应的通用性仍然受到限制，因为它们仅对某些类型的底物有用。近来，通过利用金属-配体配位键从柔性配体自组装金属-大环受体的另一种方法被认为是构建分子受体的有效方法。

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