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首页> 外文期刊>European archives of oto-rhino-laryngology: Official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) >Th1-, Th2-, and Th17-associated cytokine expression in hypopharyngeal carcinoma and clinical significance
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Th1-, Th2-, and Th17-associated cytokine expression in hypopharyngeal carcinoma and clinical significance

机译：下咽癌中Th1，Th2和Th17相关细胞因子的表达及其临床意义

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摘要

Th0 cells differentiate into Th1 or Th2 depending on multiple transcription factors acting on specific time points to regulate gene expression. Th17 cells, a subset of IL-17-producing T cells distinct from Th1 or Th2 cells, have been described as key players in inflammation and autoimmune diseases as well as cancer development. In the present study, 53 patients with hypopharyngeal cancer were included. The expression levels of Th1-, Th2- and Th17-associated cytokines in hypopharyngeal cancer tissues and pericarcinoma tissues were detected. The relationship between Th1, Th2, or Th17 infiltration and metastasis was studied. Our results showed that the mRNA and protein expressions of Th1 cytokines were lower, while the expressions of Th2 and Th17 cytokines were higher in tumor tissues, and the intensity of expression was strengthened with clinical stage increasing. Cancer tissues had higher level expressions of Th2 and Th17 cytokines than that of pericarcinoma tissues. From the above data, we speculated that high expressions of Th2- and Th17-associated cytokines in hypopharyngeal carcinoma may contribute to cancer development and metastasis.
机译：Th0细胞根据在特定时间点调控基因表达的多种转录因子分化为Th1或Th2。 Th17细胞是不同于Th1或Th2细胞的产生IL-17的T细胞的子集，已被描述为炎症和自身免疫性疾病以及癌症发展的关键因素。在本研究中，包括53例下咽癌患者。检测咽下癌组织和癌旁组织中Th1，Th2和Th17相关细胞因子的表达水平。研究了Th1，Th2或Th17浸润与转移之间的关系。我们的结果显示，在肿瘤组织中，Th1细胞因子的mRNA和蛋白表达较低，而Th2和Th17细胞因子的表达较高，并且随着临床分期的增加，表达强度增强。癌组织中Th2和Th17细胞因子的表达水平高于癌旁组织。根据以上数据，我们推测在咽咽癌中Th2和Th17相关细胞因子的高表达可能有助于癌症的发展和转移。

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