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首页> 外文期刊>European journal of mass spectrometry >Differential interactions of isomeric amino sugars with insulin studied under electrospray ionisation mass spectrometry
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Differential interactions of isomeric amino sugars with insulin studied under electrospray ionisation mass spectrometry

机译：电喷雾电离质谱研究异构氨基糖与胰岛素的微分相互作用

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摘要

Protein-ligand interactions were studied for bovine insulin-amino sugar systems under electrospray ionisation mass spectrometry conditions. The isomeric amino sugars showed differences in the relative abundance of 1: 1 protein-ligand complex formation. The electrospray ionisation and tandem mass spectrometry results of the complex clearly demonstrated that the differences in the interaction of isomeric sugars with insulin are mainly due to the differences in their gas-phase basicity. The same phenomenon is replicated in the formation of complexes between insulin and other ligands, such as amino acids, as well as in the binding of the amino sugars with amyloid β 1-40 peptide.
机译：在电喷雾电离质谱条件下研究了牛胰岛素-氨基糖系统的蛋白质-配体相互作用。异构体氨基糖在1：1蛋白质－配体复合物的相对丰度上显示出差异。该复合物的电喷雾电离和串联质谱分析结果清楚地表明，异构糖与胰岛素相互作用的差异主要是由于其气相碱性的差异。在胰岛素和其他配体（例如氨基酸）之间形成复合物，以及在氨基糖与淀粉样β1-40肽的结合中也复制了相同的现象。

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