The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3.

Kiss H; Kedra D; Kiss C; Kost-Alimova M; Yang Y; Klein G; Imreh S; Dumanski JP

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The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3.

机译：LZTFL1基因是转录图的一部分，覆盖3p21.3中公共消除区域1（C3CER1）中的250 kb。

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Deletions on 3p have been described in a large number of human tumors, suggesting the presence of a tumor suppressor gene(s). Using the elimination test, we previously defined a 1-Mb segment from human 3p21.3 (C3CER1). Genomic sequencing allowed us to construct a transcription map covering 250 kb containing five genes. We have characterized a human leucine zipper containing gene, leucine zipper transcription factor-like 1 (LZTFL1), and its mouse orthologue (Lztfl1), which was also mapped to mouse chromosome 9F. The LZTFL1 gene has two transcript isoforms displaying alternative polyadenylation. We have localized the human orthologue of the yeast SAC1 (suppressor of actin) gene as well as characterized and mapped the mouse Sac1 gene. Furthermore, the XT3 gene was characterized, encoding a member of the Na(+)/Cl(-) neurotransmitter superfamily. It has been shown that the XT3 gene had an alternatively spliced brain-specific isoform, predicted to remove 1 of 12 putative transmembrane domains. The transcription map also includes the CC chemokine receptor 9 gene (CCR9) and the LIM domain containing gene 1 (LIMD1). This work partially defines the gene content of C3CER1 that is a prerequisite for delineation of its role in tumorigenesis. Copyright 2001 Academic Press.

机译：已经在许多人类肿瘤中描述了3p的缺失，表明存在肿瘤抑制基因。使用消除测试，我们先前从人类3p21.3（C3CER1）定义了一个1-Mb片段。基因组测序使我们能够构建一个包含5个基因的250 kb的转录图。我们已经表征了人类亮氨酸拉链包含基因，亮氨酸拉链转录因子样1（LZTFL1），和它的小鼠直系同源基因（Lztfl1），也映射到小鼠9F染色体。 LZTFL1基因有两个转录亚型，显示出可替代的聚腺苷酸化。我们已经定位了酵母SAC1（肌动蛋白抑制剂）基因的人类直系同源物，以及表征和定位了小鼠Sac1基因。此外，XT3基因的特征是编码Na（+）/ Cl（-）神经递质超家族的成员。已经显示，XT3基因具有选择性剪接的脑特异性同种型，预计将除去12个推定的跨膜结构域中的1个。转录图还包括CC趋化因子受体9基因（CCR9）和含LIM结构域的基因1（LIMD1）。这项工作部分地定义了C3CER1的基因含量，这是描述其在肿瘤发生中作用的先决条件。版权所有2001，学术出版社。

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《Genomics》 |2001年第1期|共10页
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Kiss H; Kedra D; Kiss C; Kost-Alimova M; Yang Y; Klein G; Imreh S; Dumanski JP;
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正文语种 eng
中图分类遗传学;
关键词
Chromosomes; Human; Pair 3; Leucine Zippers; Transcription Factors; Carrier Proteins; 染色体; 人; 3对; 亮氨酸拉链; 转录因子;

机译：Chromosomes;Human;Pair 3;Leucine Zippers;Transcription Factors;Carrier Proteins;染色体;人;3对;亮氨酸拉链;转录因子;

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1. The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3. [J] . Kiss H, Kedra D, Kiss C, Genomics . 2001,第1期

机译：LZTFL1基因是转录图的一部分，覆盖3p21.3中公共消除区域1（C3CER1）中的250 kb。
2. The transcriptional map of the common eliminated region 1 (C3CER1) in 3p21.3. [J] . Kiss H, Yang Y, Kiss C, European journal of human genetics: EJHG . 2002,第1期

机译：3p21.3中共同消除区域1（C3CER1）的转录图。
3. A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3. [J] . Kiss H, Kedra D, Yang Y, Human Genetics . 1999,第6期

机译：包含LIM域的新基因（LIMD1）位于3p21.3中的共同消除区域1（C3CER1）中。
4. Fine genetic mapping and physical delimitation of the recessive genic male sterile gene Bnms1 to a 21-kb DNA segment in Brassica napus L [C] . YI Bin, CHEN Yuning, LEI Shaolin, Proceedings of the 12th International Rapeseed Congress: Sustainable Development in Cruciferous Oilseed Crops Production . 2007

机译：甘蓝型油菜隐性雄性不育基因Bnms1到21-kb DNA区段的精细遗传作图和物理定界
5. The Mapping of Inhibitor on Feline Chromosome D2 and a Sequence Analysis of the Genes within the Critical Region. [D] . Hamilton, Michael. 2010

机译：猫染色体D2上的抑制剂定位以及关键区域内基因的序列分析。
6. The Genomic Region Encompassing the Nephropathic Cystinosis Gene (CTNS): Complete Sequencing of a 200-kb Segment and Discovery of a Novel Gene within the Common Cystinosis-Causing Deletion [O] . Jeffrey W. Touchman, Yair Anikster, Nicole L. Dietrich, 2000

机译：包含肾病性膀胱炎基因（CTNS）的基因组区域：200 kb节段的完整测序和常见的引起膀胱炎的缺失中发现一个新基因。
7. Figure 1: Example of visualization of long range contacts for: (A) regions, here enhancer-promoter contacts, for two 10 kb resolution Hi-C maps from human Fetal Brain cells. Contacts were calculated up to 30 bins distance each way from the point of interest. Top to bottom: a Jbrowse (Skinner et al., 2009) screenshot with genes and interaction profile representation (points of interest in green, their contact predictions in yellow); HiCEnterprise interaction profile plot with intensities (weighted by distance) and −log10 of FDR corrected p-values (q-values) with a threshold set at 0.01. (B) TADs, here HiCEnterprise visualization for 150 kb resolution Hi-C map of 17th chromosome from HUVEC. Left upper trianle: original Hi-C map contact frequencies; right lower triangle: −log10 of q-values of the interdomain interactions calculated with hypergeometric distribution. [O] . -1

机译：图1：用于：（a）区域的长距离触点的可视化示例，这里增强了来自人胎儿脑细胞的两个10kb分辨率的Hi-C地图。从兴趣点计算联系人高达30个距离距离。顶部到底：jbrowse（Skinner等，2009）截图，具有基因和互动曲线表示（绿色兴趣点，它们的黄色接触预测）; HICENTERPLISE交互配置曲线图具有强度（由距离加权）和FDR校正的P值（Q值）的-LOG10，其阈值设置为0.01。（b）TADS，这里是来自Huvec的第17次染色体的150 KB分辨率Hi-C地图的Hicenterprise可视化。左上三角：原版Hi-C地图接触频率;右下三角形：跨度相互作用的Q值的-log10计算，使用超几何分布计算。

The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3.

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