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首页> 外文期刊>Genomic medicine, biomarkers, and health sciences. >Apoptotic-related gene expression in oxaliplatin-treated CCM-1 colorectal adenocarcinoma and MALT-nt-1 mucosa-associated lymphoid tissue lymphoma cell lines
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Apoptotic-related gene expression in oxaliplatin-treated CCM-1 colorectal adenocarcinoma and MALT-nt-1 mucosa-associated lymphoid tissue lymphoma cell lines

机译：奥沙利铂治疗的CCM-1大肠腺癌和MALT-nt-1黏膜相关淋巴样淋巴瘤细胞系中凋亡相关基因的表达

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摘要

The purpose of this study was to assess the apoptotic -related gene expression of single-agent oxaliplatin in vitro. Growth inhibition studies were performed using the human cerebral cavernous malformation-1 colorectal adenocarcinoma cell line and mucosa-associated lymphoid tissue-nt-1 lymphoma cell line. At 50% inhibitory concentrations, oxaliplatin displayed suppressive effects toward Bcl-2 and the surviving expression in human cancer cell lines, whereas the expression of Fas/FasL was completely abolished in peripheral blood cells. Our data showed that oxaliplatin exerts potent antiapoptotic effects in human normal peripheral blood mononuclear cells at the suprapharmacologic concentration, warranting further investigations in the role of autoimmune adverse events while being used in numerous cycles for the treatment of malignancies.
机译：这项研究的目的是评估单药奥沙利铂在体外的凋亡相关基因表达。使用人脑海绵状畸形-1结直肠腺癌细胞系和黏膜相关淋巴样组织-nt-1淋巴瘤细胞系进行了生长抑制研究。在50％的抑制浓度下，奥沙利铂对人癌细胞系中的Bcl-2和尚存的表达均显示出抑制作用，而Fas / FasL的表达在外周血细胞中被完全消除。我们的数据显示，奥沙利铂以超药理学浓度在人正常外周血单核细胞中发挥有效的抗凋亡作用，因此有必要进一步研究自身免疫不良事件的作用，同时将其用于许多周期的恶性肿瘤治疗。

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