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Expression analysis of 21 transcripts physically anchored within the chromosomal region 10q24.

机译:物理锚定在染色体区域10q24中的21个转录本的表达分析。

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摘要

Chromosome band 10q24 harbors the critical regions for inherited neurological disorders such as partial epilepsy (EPT), urofacial syndrome, and a distinct form of spastic paraparesis. To facilitate the selection of candidate genes for these diseases, we determined the mRNA sizes and analyzed the expression patterns of 21 brain transcripts defined by expressed sequence tags previously localized along a 7.4-Mb interval of 10q24. In addition to a number of widely expressed transcribed sequences, we identified several transcripts exclusively or predominantly expressed in the brain, which represent potential candidates for the neurological diseases associated with this genomic region. Copyright 1999 Academic Press.
机译:染色体带10q24包含遗传性神经系统疾病(例如部分性癫痫(EPT),尿面综合征和截然不同的痉挛性轻瘫)的关键区域。为了方便选择这些疾病的候选基因,我们确定了mRNA的大小,并分析了21个脑转录物的表达模式,这些转录物由先前位于7.4-Mb间隔10q24的表达序列标签定义。除了许多广泛表达的转录序列外,我们还鉴定了几个在大脑中专门或主要表达的转录本,它们代表了与此基因组区域相关的神经系统疾病的潜在候选者。版权所有1999 Academic Press。

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