...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Genomics >Organization of the mouse Zfhx1b gene encoding the two-handed zinc finger repressor Smad-interacting protein-1.
【24h】

Organization of the mouse Zfhx1b gene encoding the two-handed zinc finger repressor Smad-interacting protein-1.

机译：小鼠Zfhx1b基因的编码，该基因编码两只手的锌指阻抑物Smad相互作用蛋白-1。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

SIP1, a member of the deltaEF1 family of two-handed zinc finger transcriptional repressors, has been identified as a Smad-binding protein. Recently, mutations in the human SIP1 gene (ZFHX1B) have been implicated in Hirschsprung disease. Here we document extensively the structure and transcriptional pattern of the mouse SIP1 gene (Zfhx1b) and compare it to homologues from other species. The overall structure of Zfhx1b is highly similar to that of the deltaEF1 gene (Zfhx1a), confirming their close evolutionary relationship. In contrast to Zfhx1a, the 5' untranslated region of the SIP1-encoding mouse gene is very complex and includes several alternative exons. The corresponding 5'-UTR splicing pattern seems to be conserved between species and suggests a role in its transcriptional and/or translational regulation. The gene also codes for an antisense transcript that is highly conserved between human and mouse.
机译：SIP1是双手锌指转录阻遏物deltaEF1家族的成员，已被鉴定为Smad结合蛋白。最近，人类SIP1基因（ZFHX1B）的突变已被证明与Hirschsprung疾病有关。在这里，我们广泛地记录了小鼠SIP1基因（Zfhx1b）的结构和转录模式，并将其与其他物种的同源物进行了比较。 Zfhx1b的总体结构与deltaEF1基因（Zfhx1a）的高度相似，证实了它们的密切进化关系。与Zfhx1a相反，编码SIP1的小鼠基因的5'非翻译区非常复杂，并包含多个其他外显子。相应的5'-UTR剪接模式似乎在物种之间是保守的，并暗示了其转录和/或翻译调控中的作用。该基因还编码在人和小鼠之间高度保守的反义转录物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号