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首页> 外文期刊>Genomics >A search for overlapping genetic susceptibility loci between non-Hodgkin lymphoma and autoimmune diseases.
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A search for overlapping genetic susceptibility loci between non-Hodgkin lymphoma and autoimmune diseases.

机译：寻找非霍奇金淋巴瘤与自身免疫性疾病之间重叠的遗传易感基因座。

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摘要

Non-Hodgkin lymphoma (NHL) is a hematological malignancy of the immune system, and, as with autoimmune and inflammatory diseases (ADs), is influenced by genetic variation in the major histocompatibility complex (MHC). Persons with a history of specific ADs also have increased risk of NHL. As the coexistence of ADs and NHL could be caused by factors common to both diseases, here we examined whether some of the associated genetic signals are shared. Overlapping risk loci for NHL subytpes and several ADs were explored using data from genome-wide association studies. Several common genomic regions and susceptibility loci were identified, suggesting a potential shared genetic background. Two independent MHC regions showed the main overlap, with several alleles in the human leukocyte antigen (HLA) class II region exhibiting an opposite risk effect for follicular lymphoma and type I diabetes. These results support continued investigation to further elucidate the relationship between lymphoma and autoimmune diseases.
机译：非霍奇金淋巴瘤（NHL）是免疫系统的血液系统恶性肿瘤，与自身免疫和炎性疾病（ADs）一样，受到主要组织相容性复合体（MHC）遗传变异的影响。有特定AD病史的人也会增加NHL的风险。由于AD和NHL的共存可能是由两种疾病共同的因素引起的，因此在这里我们检查了一些相关的遗传信号是否被共享。使用全基因组关联研究的数据探索了NHL亚型和几个AD的重叠风险位点。确定了几个常见的基因组区域和易感基因座，表明潜在的共有遗传背景。两个独立的MHC区显示出主要重叠，人类白细胞抗原（HLA）II类区中的几个等位基因对滤泡性淋巴瘤和I型糖尿病具有相反的风险作用。这些结果支持继续研究以进一步阐明淋巴瘤与自身免疫性疾病之间的关系。

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