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Analysis of the vomeronasal receptor repertoire, expression and allelic diversity in swine

机译：猪中鼻息肉受体组成，表达和等位基因多样性的分析

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Here we report a comprehensive analysis of the vomeronasal receptor repertoire in pigs. We identified a total of 25 V1R sequences consisting of 10 functional genes, 3 pseudogenes, and 12 partial genes, while functional V2R and FPR genes were not present in the pig genome. Pig V1Rs were classified into three subfamilies, D, F, and J. Using direct high resolution sequencing-based typing of all functional V1Rs from 10 individuals of 5 different breeds, a total of 24 SNPs were identified, indicating that the allelic diversity of V1Rs is much lower than that of the olfactory receptors. A high expression level of V1Rs was detected in the vomeronasal organ (VNO) and testes, while a low expression level of V1Rs was observed in all other tissues examined. Our results showed that pigs could serve as an interesting large animal model system to study pheromone-related neurobiology because of their genetic simplicity. (C) 2015 Published by Elsevier Inc.
机译：在这里，我们报告对猪的犁鼻器受体库的全面分析。我们鉴定出总共25个V1R序列，由10个功能基因，3个假基因和12个部分基因组成，而功能性V2R和FPR基因在猪基因组中不存在。猪V1R被分为D，F和J三个亚科。使用基于高分辨率测序的直接分型，对来自5个不同品种的10个个体的所有功能性V1R进行鉴定，总共鉴定出24个SNP，表明V1R的等位基因多样性远低于嗅觉受体。在犁鼻鼻器官（VNO）和睾丸中检测到V1Rs的高表达水平，而在所有其他检查的组织中观察到V1Rs的低表达水平。我们的结果表明，猪具有遗传简单性，因此可以作为研究信息素相关神经生物学的有趣大型动物模型系统。 （C）2015年由Elsevier Inc.出版

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