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Relationship of long noncoding RNA and viruses

机译:长非编码RNA与病毒的关系

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Long noncoding (lnc) RNAs comprise a diverse group of transcripts including large intervening noncoding (linc) RNAs, natural antisense transcripts (NATs) and intronic lncRNAs. The functions and mechanisms of more than 200 lncRNAs have been studied in vitro and the results suggest that lncRNAs may be molecular markers of prognosis in cancer patients. Some lncRNAs can promote virus replication and allowescape from cytosolic surveillance to suppress antiviral immunity. For example, lncRNA can cause persistent infection by Theiler's virus, and microRNA (miR)-27a/b is important for efficientmurine cytomegalovirus (MCMV) replication. The available evidence suggests that lncRNAs may be potential targets of novel antiviral drugs. (C) 2016 The Authors. Published by Elsevier Inc.
机译:长的非编码(lnc)RNA包含多种转录本,包括较大的中间非编码(linc)RNA,天然反义转录本(NAT)和内含子lncRNA。已经对200多个lncRNA的功能和机制进行了体外研究,结果表明lncRNA可能是癌症患者预后的分子标志。一些lncRNAs可以促进病毒复制并从胞质监视中逃逸,从而抑制抗病毒免疫。例如,lncRNA可以导致泰勒病毒持续感染,而microRNA(miR)-27a / b对于有效的鼠巨细胞病毒(MCMV)复制很重要。现有证据表明,lncRNAs可能是新型抗病毒药物的潜在靶标。 (C)2016作者。由Elsevier Inc.发布

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