Characterization of the type I interferon locus and identification of novel genes.

Hardy MP; Owczarek CM; Jermiin LS; Ejdeback M; Hertzog PJ

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Characterization of the type I interferon locus and identification of novel genes.

机译：I型干扰素基因座的表征和新基因的鉴定。

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The human type I interferon (IFN) genes are clustered on human chromosome 9p21 and the mouse genes are located in the region of conserved synteny on mouse chromosome 4. We have identified two novel mouse Ifna genes (Ifna12, Ifna13) and Ifnl2 (IFN-like 2, a homologue of Limitin/IFN-like 1). Another type I IFN gene was designated Ifne1. Mouse Ifne1 was expressed in ovaries and uterus but not in tissues of hematopoietic origin. IFN-1 has general structural characteristics of a type I IFN. These studies represent the first detailed annotation of the mouse type I IFN locus, and the products of these novel genes may have important functions in reproduction and host defense.

机译：人类I型干扰素（IFN）基因聚集在人类9p21染色体上，小鼠基因位于小鼠4号染色体上的保守同调区域。我们已经鉴定出两个新颖的小鼠Ifna基因（Ifna12，Ifna13）和Ifnl2（IFN-像2，是Limitin / IFN-like 1的同源物。另一个I型IFN基因被命名为Ifne1。小鼠Ifne1在卵巢和子宫中表达，但在造血起源的组织中不表达。 IFN-1具有I型IFN的一般结构特征。这些研究代表了小鼠I型IFN基因座的第一个详细注释，这些新基因的产物可能在繁殖和宿主防御中具有重要功能。

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来源
《Genomics》 |2004年第2期|共15页
作者
Hardy MP; Owczarek CM; Jermiin LS; Ejdeback M; Hertzog PJ;
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正文语种 eng
中图分类基础医学;
关键词
novel; Laboratory mice; Interferons; Human; Chromosomes; 干扰素类; 染色体;

机译：novel;Laboratory mice;Interferons;Human;Chromosomes;干扰素类;染色体;

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1. Characterization of the type I interferon locus and identification of novel genes. [J] . Hardy MP, Owczarek CM, Jermiin LS, Genomics . 2004,第2期

机译：I型干扰素基因座的表征和新基因的鉴定。
2. Identification of a Sj?gren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons [J] . He Li, Tove Ragna Reksten, John A. Ice, PLoS Genetics . 2017,第6期

机译：在<斜体> OAS1 中鉴定SJ？GREN的综合征敏感性座位，影响同种型切换，蛋白质表达和I型干扰素的反应性
3. Plasmid double locus sequence typing for IncHI2 plasmids, a subtyping scheme for the characterization of IncHI2 plasmids carrying extended-spectrum beta-lactamase and quinolone resistance genes. [J] . Garcia Fernandez A, Carattoli A The Journal of Antimicrobial Chemotherapy . 2010,第6期

机译：IncHI2质粒的质粒双基因座序列分型，这是表征携带超广谱β-内酰胺酶和喹诺酮抗性基因的IncHI2质粒的子分型方案。
4. LC-MS/MS-BASED CHARACTERIZATION OF GLIOBLASTOMA CELL RESPONSES TO TYPE I INTERFERONS FOR ESTABLISHING DEFECTS IN ANTIVIRAL MECHANISMS [C] . Irina Tarasova, Alesya Tereshkova, Elizaveta Solovyeva, International Mass Spectrometry Conference . 2018

机译：基于LC-MS / MS的胶质母细胞瘤细胞对I型干扰素的表征，用于在抗病毒机制中建立缺陷
5. Molecular characterization of type I and type II interferons and identification of interferon stimulated genes in channel catfish. [D] . Milev-Milovanovic, Ivanka. 2008

机译：channel鱼中I型和II型干扰素的分子特征以及干扰素刺激基因的鉴定。
6. Characterization of a mouse interferon gene locus I. Isolation of a cluster of four alpha interferon genes. [O] . K A Kelley, P M Pitha 1985

机译：小鼠干扰素基因位点的表征I.分离出四个α干扰素基因簇。
7. Identification of a Sjögrens syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons [O] . Li, He, Ragna Reksten, Tove, Ice, John A., 2017

机译：在OAS1鉴定出一个Sjögrens综合征易感基因座，该基因座影响同工型转换，蛋白质表达和对I型干扰素的反应性

Characterization of the type I interferon locus and identification of novel genes.

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