Integrated approaches to uncovering transcription regulatory networks in mammalian cells.

Tan K; Tegner J; Ravasi T

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Integrated approaches to uncovering transcription regulatory networks in mammalian cells.

机译：在哺乳动物细胞中发现转录调控网络的综合方法。

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Integrative systems biology has emerged as an exciting research approach in molecular biology and functional genomics that involves the integration of genomics, proteomics, and metabolomics datasets. These endeavors establish a systematic paradigm by which to interrogate, model, and iteratively refine our knowledge of the regulatory events within a cell. Here we review the latest technologies available to collect high-throughput measurements of a cellular state as well as the most successful methods for the integration and interrogation of these measurements. In particular we will focus on methods available to infer transcription regulatory networks in mammals.

机译：集成系统生物学已成为分子生物学和功能基因组学中令人兴奋的研究方法，涉及基因组学，蛋白质组学和代谢组学数据集的整合。这些努力建立了系统的范式，通过它可以询问，建模和迭代地完善我们对细胞内调控事件的了解。在这里，我们回顾了可用于收集细胞状态高通量测量的最新技术，以及用于这些测量的集成和询问的最成功方法。特别是，我们将重点介绍可用于推断哺乳动物转录调控网络的方法。

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《Genomics》 |2008年第3期|共13页
作者
Tan K; Tegner J; Ravasi T;
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正文语种 eng
中图分类遗传学;
关键词
Animals; Computational Biology; Databases; Factual; Genomics; Humans; Mammals; 动物; 计算生物学; 数据库; 事实型; 哺乳动物; 代谢; 反式激活(遗传学);

机译：Animals;Computational Biology;Databases;Factual;Genomics;Humans;Mammals;动物;计算生物学;数据库;事实型;哺乳动物;代谢;反式激活(遗传学);

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1. Integrated approaches to uncovering transcription regulatory networks in mammalian cells. [J] . Tan K, Tegner J, Ravasi T Genomics . 2008,第3期

机译：在哺乳动物细胞中发现转录调控网络的综合方法。
2. RegNetwork: an integrated database of transcriptional and post-transcriptional regulatory networks in human and mouse [J] . Canglin Wu, Hongyu Miao, Hulin Wu, Database . 2015,第2012期

机译：RegNetwork：人类和小鼠中转录和转录后调控网络的集成数据库
3. Uncovering MicroRNA and Transcription Factor Mediated Regulatory Networks in Glioblastoma [J] . Jingchun Sun, Xue Gong, Benjamin Purow, PLoS Computational Biology . 2012,第7期

机译：在胶质母细胞瘤中发现MicroRNA和转录因子介导的调控网络。
4. Uncovering transcriptional regulatory networks by sparse Bayesian factor model [C] . IEEE 10th International Conference on Signal Processing . 2010

机译：通过稀疏贝叶斯因子模型发现转录调控网络
5. Uncovering mammalian transcriptional regulatory mechanisms by computational approaches. [D] . Chang, Li-Wei. 2006

机译：通过计算方法揭示哺乳动物转录调控机制。
6. RegNetwork: an integrated database of transcriptional and post-transcriptional regulatory networks in human and mouse [O] . Zhi-Ping Liu, Canglin Wu, Hongyu Miao, 2015

机译：RegNetwork：人类和小鼠的转录和转录后调控网络的集成数据库
7. Integrated approaches to uncovering transcription regulatory networks in mammalian cells [O] . Tan Kai, Tegner Jesper, Ravasi Timothy 2008

机译：揭示哺乳动物细胞转录调控网络的综合方法

Integrated approaches to uncovering transcription regulatory networks in mammalian cells.

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