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首页> 外文期刊>Genomics >Polymorphisms in the interleukin-1 (IL1) gene cluster are not associated with aggressive periodontitis in a large Caucasian population.
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Polymorphisms in the interleukin-1 (IL1) gene cluster are not associated with aggressive periodontitis in a large Caucasian population.

机译：白细胞介素1（IL1）基因簇中的多态性与高加索人口中的侵略性牙周炎无关。

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摘要

Polymorphisms in the interleukin-1 (IL1) gene have been suggested to influence transcription of IL1A (interleukin-1alpha) and IL1B (interleukin-1beta) and thereby the pathophysiology of periodontitis. This case-control association study on 415 northern European Caucasian patients with aggressive periodontitis (AgP) and 874 healthy controls was conducted to examine 10 single-nucleotide polymorphisms (SNPs) in the genes of the IL1 cluster for association with IL1A, IL1B, CKAP2L (cytoskeleton-associated protein 2-like), and IL1RN (IL-1 receptor antagonist). The results do not support an association between variants in the IL1 gene cluster and AgP. This case-control study had at least 95% power to detect genuine associations with variants carrying relative risks of at least 1.5 for heterozygous carriers and 2.25 for homozygous carriers. Previous reports of an association between IL1 promoter SNPs and periodontitis might reflect subpopulation effects and have to be interpreted with care.
机译：已经提出白介素-1（IL1）基因中的多态性影响IL1A（白介素-1alpha）和IL1B（白介素-1beta）的转录，从而影响牙周炎的病理生理。这项针对415名北欧白种人侵袭性牙周炎（AgP）和874名健康对照的病例对照研究旨在检查IL1簇基因中的10个单核苷酸多态性（SNP）与IL1A，IL1B，CKAP2L相关（细胞骨架相关蛋白2样）和IL1RN（IL-1受体拮抗剂）。结果不支持IL1基因簇中的变体与AgP之间的关联。这项病例对照研究具有至少95％的能力，可以检测与杂合子携带者相对风险至少为1.5且纯合子携带者相对风险为2.25的变体之间的真实关联。先前有关IL1启动子SNP与牙周炎之间相关性的报道可能反映了亚群效应，必须谨慎解释。

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