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DHPC: a new tool to express genome structural features.

机译:DHPC:表达基因组结构特征的新工具。

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摘要

The DHPC (DNA Hilbert-Peano curve) is a new tool for visualizing large-scale genome sequences by mapping sequences into a two-dimensional square. It utilizes the space-filling function of Hilbert-Peano mapping. By applying a Gauss smoothing technique and a user-defined color function, a large-scale genome sequence can be mapped into a two-dimensional color image. In the calculated DHPCs, many genome characteristics are revealed. In this article we introduce the method and show how DHPCs may be used to identify regions of different base composition. The power of the method is demonstrated by presenting multiple examples such as repeating sequences, degree of base bias, regions of homogeneity and their boundaries, and mark of annotated segments. We also present several genome curves generated by DHPC to demonstrate how DHPC can be used to find previously unidentified sequence features in these genomes.
机译:DHPC(DNA Hilbert-Peano曲线)是一种通过将序列映射到二维正方形中来可视化大规模基因组序列的新工具。它利用了Hilbert-Peano映射的空间填充功能。通过应用高斯平滑技术和用户定义的颜色函数,可以将大规模的基因组序列映射到二维彩色图像中。在计算的DHPC中,揭示了许多基因组特征。在本文中,我们介绍了该方法,并说明了如何将DHPC用于识别不同碱基组成的区域。通过展示多个示例(例如重复序列,碱基偏倚程度,同质性区域及其边界以及带注释的段的标记),可以证明该方法的强大功能。我们还介绍了由DHPC生成的几个基因组曲线,以演示DHPC如何可用于在这些基因组中找到以前未鉴定的序列特征。

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