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首页> 外文期刊>Genomics >Amplicons on human chromosome 11q are located in the early/late-switch regions of replication timing.
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Amplicons on human chromosome 11q are located in the early/late-switch regions of replication timing.

机译：人类染色体11q上的扩增子位于复制时间的早期/晚期转换区域。

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Amplicons are frequently found in human tumor genomes, but the mechanism of their generation is still poorly understood. We previously measured the replication timing of the genes along the entire length of human chromosomes 11q and 21q and found that many "disease-related" genes are located in timing-transition regions. In this study, further scrutiny of the updated replication-timing map of human chromosome 11q revealed that both amplicons on human chromosomal bands 11q13 and 11q22 are located in the early/late-switch regions of replication timing in two human cell lines (THP-1 and Jurkat). Moreover, examination of synteny in the human and mouse genomes revealed that synteny breakage in both genomes occurred primarily at the early/late-switch regions of replication timing that we had identified. In conclusion, we found that the early/late-switch regions of replication timing coincided with "unstable" regions of the genome.
机译：扩增子通常在人类肿瘤基因组中发现，但其生成机理仍知之甚少。我们先前测量了人类染色体11q和21q整个长度上基因的复制时间，发现许多“疾病相关”基因位于时间转换区域。在这项研究中，进一步检查了人类11q染色体的更新复制时序图后发现，人类染色体11q13和11q22染色体上的两个扩增子均位于两个人类细胞系（THP-1）的复制时序的早期/晚期转换区域中。和Jurkat）。此外，在人类和小鼠基因组中的同调检查表明，两个基因组中的同调断裂主要发生在我们确定的复制时机的早期/后期转换区域。总之，我们发现复制时机的早期/后期转换区域与基因组的“不稳定”区域重合。

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