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首页> 外文期刊>Genomics >Comparison of assembled Clostridium botulinum A1 genomes revealed their evolutionary relationship.
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Comparison of assembled Clostridium botulinum A1 genomes revealed their evolutionary relationship.

机译：比较组装的肉毒梭菌A1基因组，揭示了它们的进化关系。

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摘要

Clostridium botulinum encompasses bacteria that produce at least one of the seven serotypes of botulinum neurotoxin (BoNT/A-G). The availability of genome sequences of four closely related Type A1 or A1(B) strains, as well as the A1-specific microarray, allowed the analysis of their genomic organizations and evolutionary relationship. The four genomes share >90% core genes and >96% functional groups. Phylogenetic analysis based on COG shows closer relations of the A1(B) strain, NCTC 2916, to B1 and F1 than A1 strains. Alignment of the genomes of the three A1 strains revealed a highly similar chromosomal structure with three small gaps in the genome of ATCC 19397 and one additional gap in the genome of Hall A, suggesting ATCC 19379 as an evolutionary intermediate between Hall A and ATCC 3502. Analyses of the four gap regions indicated potential horizontal gene transfer and recombination events important for the evolution of A1 strains.
机译：肉毒杆菌包括产生至少七种肉毒杆菌神经毒素血清型（BoNT / A-G）的细菌。四个密切相关的A1型或A1（B）型菌株的基因组序列的可获得性，以及A1特异性微阵列，可以对其基因组组织和进化关系进行分析。四个基因组共享> 90％的核心基因和> 96％的官能团。基于COG的系统发育分析显示，与A1菌株相比，A1（B）菌株NCTC 2916与B1和F1的关系更紧密。三种A1菌株的基因组比对显示出高度相似的染色体结构，在ATCC 19397的基因组中有三个小缺口，在Hall A的基因组中又有一个缺口，表明ATCC 19379是Hall A和ATCC 3502之间的进化中间体。四个缺口区域的分析表明潜在的水平基因转移和重组事件对A1菌株的进化很重要。

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