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首页> 外文期刊>Genomics >Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors.
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Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors.

机译：痕量胺相关受体形成新型G蛋白偶联受体的结构和功能不同的亚家族。

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摘要

Trace amines are endogenous compounds structurally related to classical biogenic amines that have been studied for decades, triggered by their link to psychiatric conditions of high epidemiological and economical relevance. The understanding of their pharmacology on the molecular level was hampered until the recent discovery of trace-amine-specific receptors. We completed the identification of all members of this novel GPCR family in human, chimpanzee, rat, and mouse and observed remarkable interspecies differences, even between human and chimpanzee. The analysis of the chromosomal localizations, phylogenetic relationships, and ligand pocket vectors reveals three distinct receptor subfamilies. As most of these receptors do not respond to trace amines, each subfamily will presumably have a distinct pharmacological profile, which remains to be identified. We propose a uniform nomenclature describing this novel GPCR family in all mammalian species as trace-amine-associated receptors (TAARs), which resolves the ambiguities and contradictions of the previous naming.
机译：痕量胺是与经典生物胺在结构上相关的内源性化合物，由于其与高度流行病学和经济相关的精神病学状况之间的联系而被研究了数十年。直到最近发现了痕量胺特异性受体，才阻碍了对它们在分子水平上药理学的理解。我们完成了在人类，黑猩猩，大鼠和小鼠中对这一新型GPCR家族的所有成员的鉴定，并观察到了显着的种间差异，甚至在人类和黑猩猩之间也是如此。染色体定位，系统发育关系和配体口袋载体的分析揭示了三个不同的受体亚家族。由于这些受体中的大多数对痕量胺均无反应，因此每个亚家族可能具有不同的药理作用，尚待确定。我们提出一个统一的命名法，将所有哺乳动物物种中的这种新型GPCR家族描述为痕量胺相关受体（TAAR），从而解决了先前命名的歧义和矛盾。

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