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首页> 外文期刊>Genomics >Fishy taint in chicken eggs is associated with a substitution within a conserved motif of the FMO3 gene.
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Fishy taint in chicken eggs is associated with a substitution within a conserved motif of the FMO3 gene.

机译：鸡蛋中的腥味与FMO3基因保守基序内的取代有关。

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摘要

Fishy odor of urine and other secretions is a characteristic of trimethylaminuria in humans, resulting from loss-of-function mutations in the flavin-containing mono-oxygenase isoform FMO3. A similar phenotype exists in cattle, in which a nonsense mutation in the bovine orthologue causes fishy off-flavor in cow's milk. The fishy odor is caused by an elevated level of excreted odorous trimethylamine (TMA), due to deficient oxidation of TMA. We report the mapping of a similar disorder (fishy taint of eggs) and the chicken FMO3 gene to chicken chromosome 8. The only nonsynonymous mutation identified in the chicken FMO3 gene (T329S) changes an evolutionarily highly conserved amino acid and is associated with elevated levels of TMA and fishy taint in the egg yolk in several chicken lines. No differences in the expression of FMO3 were found among individuals with different associated genotypes, indicating that the trait is not caused by a linked polymorphism causing altered expression of the gene. The resultssupport the importance and function of the evolutionarily conserved motif FATGY, which has been speculated to be a substrate recognition pocket of N-hydroxylating siderophore enzymes and flavin-containing mono-oxygenases.
机译：尿液和其他分泌物的腥臭味是人类三甲基尿症的特征，这是由含黄素的单加氧酶同工型FMO3的功能丧失突变引起的。牛也存在类似的表型，其中牛直向同源物的无意义突变导致牛奶中的鱼腥味。鱼腥味是由于TMA氧化不足导致排泄的臭味三甲胺（TMA）水平升高所致。我们报告了类似的疾病（卵的鱼腥味）和鸡FMO3基因到鸡8号染色体的映射。在鸡FMO3基因（T329S）中鉴定出的唯一非同义突变改变了进化上高度保守的氨基酸，并与水平升高相关几种鸡系的蛋黄中的TMA和鱼腥味的变化。在具有不同相关基因型的个体之间未发现FMO3的表达差异，这表明该性状不是由导致基因表达改变的连锁多态性引起的。结果支持进化保守的基序FATGY的重要性和功能，该结构被认为是N-羟基化铁载体酶和含黄素的单加氧酶的底物识别口袋。

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