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Sense and antisense Foxl2 transcripts in mouse.

机译：小鼠中的有义和反义Foxl2转录本。

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FOXL2 is a forkhead transcription factor involved in eyelid development and in the development and adult function of the ovary in mammals. In mouse, we have previously suggested the existence of two mRNA isoforms of Foxl2 that result from an alternative polyadenylation. In this study, we characterize in depth the structure and expression of these two variants. We also describe an antisense transcript that overlaps the whole Foxl2 transcription unit. This antisense transcript, called Foxl2OS (for opposite strand), yields several isoforms resulting from alternative splicing. No significant coding region was found in the Foxl2OS sequence. Foxl2OS displays a pattern of expression very similar to that of Foxl2 in the gonads during development and at the adult age. RNA FISH experiments show that both transcripts are expressed in the same cells at the same time. We suggest that Foxl2OS is a noncoding antisense RNA that may be involved in the regulation of Foxl2. All in all our results provide new insights about the organization of the murine Foxl2 locus. This might help us understand its regulation and function.
机译：FOXL2是涉及哺乳动物眼睑发育以及卵巢发育和成年功能的叉头转录因子。在小鼠中，我们以前曾提出过Foxl2的两个mRNA同工型的存在，这是由另一种聚腺苷酸化引起的。在这项研究中，我们深入表征了这两个变体的结构和表达。我们还描述了与整个Foxl2转录单位重叠的反义转录物。这种反义转录本，称为Foxl2OS（用于相反链），可产生来自可变剪接的几种同工型。在Fox12OS序列中未找到明显的编码区。 Foxl2OS在发育期间和成年时在性腺中显示出与Foxl2非常相似的表达模式。 RNA FISH实验表明，两种转录本均在同一细胞中同时表达。我们建议Foxl2OS是一个非编码反义RNA，可能参与Foxl2的调控。总而言之，我们的结果提供了有关小鼠Foxl2基因座组织的新见解。这可能有助于我们了解其规则和功能。

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