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首页> 外文期刊>Genomics >Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22.
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Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22.

机译：从7q22常见缺失片段中分离和分析候选髓样肿瘤抑制基因。

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摘要

Monosomy 7 and deletions of 7q are recurring leukemia-associated cytogenetic abnormalities that correlate with adverse outcomes in children and adults. We describe a 2.52-Mb genomic DNA contig that spans a commonly deleted segment of chromosome band 7q22 identified in myeloid malignancies. This interval currently includes 14 genes, 19 predicted genes, and 5 predicted pseudogenes. We have extensively characterized the FBXL13, NAPE-PLD, and SVH genes as candidate myeloid tumor suppressors. FBXL13 encodes a novel F-box protein, SVHis a member of a gene family that contains Armadillo-like repeats, and NAPE-PLD encodes a phospholipase D-type phosphodiesterase. Analysis of a panel of leukemia specimens with monosomy 7 did not reveal mutations in these or in the candidate genes LRRC17, PRO1598, and SRPK2. This fully sequenced and annotated contig provides a resource for candidate myeloid tumor suppressor gene discovery.
机译：Monosomy 7和7q缺失是与儿童和成人不良结局相关的复发性白血病相关的细胞遗传学异常。我们描述了一个2.52-Mb基因组DNA重叠群，它跨越了在髓系恶性肿瘤中确定的染色体带7q22的通常删除的部分。该间隔目前包括14个基因，19个预测基因和5个预测假基因。我们已经广泛地表征了FBXL13，NAPE-PLD和SVH基因作为候选髓样肿瘤抑制剂。 FBXL13编码一种新的F-box蛋白，SVHis是一个包含犰狳样重复序列的基因家族的成员，而NAPE-PLD编码一种磷脂酶D型磷酸二酯酶。对一组具有7号单体性的白血病标本的分析未发现这些基因或候选基因LRRC17，PRO1598和SRPK2中的突变。该全序列和带注释的重叠群为候选骨髓肿瘤抑制基因的发现提供了资源。

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