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首页> 外文期刊>Genomics >Parent genes of retrotransposition-generated gene duplicates in Drosophila melanogaster have distinct expression profiles.
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Parent genes of retrotransposition-generated gene duplicates in Drosophila melanogaster have distinct expression profiles.

机译：在果蝇中由逆转座产生的基因重复体的亲本基因具有不同的表达谱。

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摘要

Genes arising by retrotransposition are always different from their parent genes from the outset. In addition, the cDNA must insert into a region that allows expression or it will become a processed pseudogene. We sought to determine whether this class of gene duplication differs from other gene duplications based on functional criteria. Using amino acid sequences from Drosophila melanogaster, we identified retroduplicated gene pairs at various levels of sequence identity. Analysis of gene ontology annotations showed some enrichment of retroduplications in the cellular physiological processes class. Retroduplications show a higher level of nucleotide substitution than other gene duplications, suggesting a higher rate of divergence. Remarkably, analysis of microarray data for gene expression during embryogenesis showed that parent genes are more highly expressed relative to their retroduplicated copies, tandem duplications, and all genes. Furthermore, an expressed sequence tag library representation shows a broader distribution for parent genes than for all other genes and, as found previously by others, retroduplicated gene transcripts are found most abundantly in testes. Therefore, in examining retroduplicated gene pairs, we have found that parent genes of retroduplications are also a distinctive class in terms of transcript expression levels and distribution.
机译：从一开始，由逆转座产生的基因总是与它们的亲本基因不同。此外，cDNA必须插入允许表达的区域，否则它将成为经过加工的假基因。我们试图根据功能标准确定此类基因重复与其他基因重复是否不同。使用果蝇果蝇的氨基酸序列，我们在各种序列同一性水平上鉴定了重复复制的基因对。基因本体注释的分析显示了细胞生理过程类别中的重复复制的丰富。重复复制显示出比其他基因复制更高的核苷酸取代水平，表明更高的发散率。值得注意的是，对微阵列数据进行胚胎发生过程中基因表达的分析表明，相对于其反向重复拷贝，串联重复和所有基因，亲本基因的表达更高。此外，表达的序列标签文库表示与其他所有基因相比，亲本基因的分布范围更广，而且正如其他人先前发现的那样，在睾丸中发现了最丰富的逆转录基因转录本。因此，在检查反复制基因对时，我们发现反复制的亲本基因在转录表达水平和分布方面也是独特的一类。

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