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首页> 外文期刊>Genomics >Cell cycle-dependent nucleosome occupancy at cohesin binding sites in yeast chromosomes.
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Cell cycle-dependent nucleosome occupancy at cohesin binding sites in yeast chromosomes.

机译：细胞周期依赖性核小体在酵母染色体中黏附素结合位点的占有率。

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摘要

In the budding yeast, cohesin is loaded onto the chromosome during the late G1 phase, establishes sister chromatid cohesion concomitant with DNA replication, and dissociates by the telophase. Here, using oligonucleotide tiling arrays, we show that, at the anaphase, nearly all of the cohesin binding sites contain nucleosome-free regions. The majority of these sites remain nucleosome-free throughout the cell cycle, consistent with the suggestion of a DNA-binding anchoring protein present at these sites, although such a region could also serve as part of a marker for the binding of cohesin in the next cell cycle. However, a third of these sites are remodeled in the G1 phase, being reoccupied by nucleosomes by the G1/S boundary, though their subsequent removal in the S phase appears to be independent of DNA replication. Whether this difference is a result of other functions of cohesin or of the chromatin remains to be elucidated.
机译：在出芽的酵母中，黏附素在G1晚期被加载到染色体上，与DNA复制同时建立了染色单体的内聚力，并在末期解离。在这里，我们使用寡核苷酸切片阵列，表明在后期，几乎所有的粘着蛋白结合位点都包含无核小体的区域。这些位点中的大多数在整个细胞周期中都保持无核小体的状态，这与这些位点上存在DNA结合锚定蛋白的建议相符，尽管这样的区域也可以作为下一阶段结合素结合的标志物的一部分。细胞周期。但是，这些位点的三分之一在G1期被重塑，被核小体通过G1 / S边界重新占据，尽管随后在S期中的去除似乎与DNA复制无关。这种差异是否是黏附素或染色质的其他功能的结果尚待阐明。

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