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首页> 外文期刊>Genomics >TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.
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TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.

机译：TBC1D3是一种类人癌蛋白，由位于染色体17q12上的旁系同源物簇编码。

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摘要

TBC1D3 is a member of the TBC1 domain family of proteins that stimulates the intrinsic GTPase activity of RAB5A, an essential actor in early endosome trafficking. Oncogenic properties of TBC1D3 have been demonstrated previously both in vitro and in mouse models. Although the oncogenic mechanism of TBC1D3 has yet to be elucidated, the TBC1D3 locus (chromosome 17q12) is amplified in 15% of primary prostate tumors. Here, we describe eight highly related TBC1D3 paralogues located within that genomic region, potentially encoding six variant TBC1D3 proteins. We found that human tissues display specific transcription patterns of these paralogues. Furthermore, that pattern was altered in several primary prostate tumors in comparison to healthy prostate tissues. Potential TBC1D3 oncogenic mechanisms are discussed in light of these results.
机译：TBC1D3是TBC1域蛋白家族的成员，该蛋白可刺激RAB5A的固有GTP酶活性，RAB5A是早期内体运输中的重要角色。先前已经在体外和小鼠模型中证明了TBC1D3的致癌特性。尽管尚未阐明TBC1D3的致癌机制，但在15％的原发性前列腺肿瘤中会放大TBC1D3基因座（染色体17q12）。在这里，我们描述了位于该基因组区域内的八个高度相关的TBC1D3旁系同源物，可能编码六个变异的TBC1D3蛋白。我们发现人体组织显示这些旁系同源物的特定转录模式。此外，与健康前列腺组织相比，该模式在一些原发性前列腺肿瘤中有所改变。根据这些结果讨论了潜在的TBC1D3致癌机制。

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