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首页> 外文期刊>Genomics >Atypical structure and phylogenomic evolution of the new eutherian oocyte- and embryo-expressed KHDC1/DPPA5/ECAT1/OOEP gene family.
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Atypical structure and phylogenomic evolution of the new eutherian oocyte- and embryo-expressed KHDC1/DPPA5/ECAT1/OOEP gene family.

机译：新的以欧洲人卵母细胞和胚胎表达的KHDC1 / DPPA5 / ECAT1 / OOEP基因家族的非典型结构和系统进化。

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摘要

Several recent studies have shown that genes specifically expressed by the oocyte are subject to rapid evolution, in particular via gene duplication mechanisms. In the present work, we have focused our attention on a family of genes, specific to eutherian mammals, that are located in unstable genomic regions. We have identified two genes specifically expressed in the mouse oocyte: Khdc1a (KH homology domain containing 1a, also named Ndg1 for Nur 77 downstream gene 1, a target gene of the Nur77 orphan receptor), and another gene structurally related to Khdc1a that we have renamed Khdc1b. In this paper, we show that Khdc1a and Khdc1b belong to a family of several members including the so-called developmental pluripotency A5 (Dppa5) genes, the cat/dog oocyte expressed protein (cat OOEP and dog OOEP) genes, and the ES cell-associated transcript 1 (Ecat1) genes. These genes encode structurally related proteins that are characterized by an atypical RNA-binding KH domain and are specifically expressed in oocytes and/or embryonic stem cells. They are absent in fish, bird, and marsupial genomes and thus seem to have first appeared in eutherian mammals, in which they have evolved rapidly. They are located in a single syntenic region in all mammalian genomes studied, except in rodents, in which a synteny rupture due to a paracentric inversion has separated this gene family into two genomic regions and seems to be associated with increased instability in these regions. Overall, we have identified and characterized a novel family of oocyte and/or embryonic stem cell-specific genes encoding proteins that share an atypical KH RNA-binding domain and that have evolved rapidly since their emergence in eutherian mammalian genomes.
机译：最近的一些研究表明，由卵母细胞特异性表达的基因正在快速进化，特别是通过基因复制机制。在当前的工作中，我们将注意力集中在位于不稳定的基因组区域中的，特定于欧亚哺乳动物的基因家族。我们已经确定了两个在小鼠卵母细胞中特异性表达的基因：Khdc1a（含有1a的KH同源域，也称为Nur 77下游基因1（Nur77孤儿受体的靶基因）的Ndg1），以及另一个与Khdc1a结构相关的基因重命名为Khdc1b。在本文中，我们显示Khdc1a和Khdc1b属于几个成员的家族，包括所谓的发育多能性A5（Dppa5）基因，猫/狗卵母细胞表达蛋白（cat OOEP和dog OOEP）基因以及ES细胞相关转录本1（Ecat1）基因。这些基因编码结构相关的蛋白质，其特征在于非典型的结合RNA的KH结构域，并在卵母细胞和/或胚胎干细胞中特异性表达。它们不存在于鱼类，鸟类和有袋动物的基因组中，因此似乎首先出现在以欧亚哺乳动物中，它们在其中迅速发展。它们位于所有研究的哺乳动物基因组中的单一同义区域中，除了啮齿动物外，在啮齿动物中，由于同心逆转而导致的同义破裂将该基因家族分为两个基因组区域，并且似乎与这些区域中增加的不稳定性有关。总体而言，我们已经鉴定并鉴定了一个新的卵母细胞和/或胚胎干细胞特异性基因家族，它们编码共享非典型KH RNA结合结构域的蛋白质，并且自从它们在真人哺乳动物基因组中出现以来就发展迅速。

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