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首页> 外文期刊>Genomics >Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q.
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Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q.

机译：白细胞介素1受体簇：人染色体2q上IL1R2，IL1R1，IL1RL2（IL-1Rrp2），IL1RL1（T1 / ST2）和IL18R1（IL-1Rrp）的基因组织。

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The family of interleukin-1 receptor-like genes currently has six known members. We have constructed a contig of 10 overlapping human PAC clones that covers 530 kb and includes five of the six family members. The termini of the contig were mapped to the interval between D2S373 and D2S176 (chromosome 2q12) by radiation hybrid mapping. The contig contains the genes (cen --> tel), in the order given, for the type II interleukin-1 (IL-1) receptor (IL1R2), the type I IL-1 receptor (IL1R1), the IL-1 receptor-related protein 2 (IL1RL2), T1/ST2/fit-1 (IL1RL1), and the IL-1 receptor-related protein 1, which has recently been shown to be a component of the IL-18 receptor (IL18R1). We show that all the genes are transcribed in the same direction, with IL1R2 being transcribed toward the cluster. The only known family member that is absent from the human contig is the IL-1 receptor accessory protein gene (IL1RAP), which maps to 3q28. Copyright 1999 Academic Press.
机译：白介素-1受体样基因家族目前有六个已知成员。我们已经构建了一个10个重叠的人PAC克隆的重叠群，覆盖530 kb，包括六个家族成员中的五个。重叠群的末端通过辐射杂交作图被映射到D2S373和D2S176（染色体2q12）之间的间隔。重叠群包含基因（cen-> tel），按给定顺序包含II型白介素1（IL-1）受体（IL1R2），I型IL-1受体（IL1R1），IL-1受体相关蛋白2（IL1RL2），T1 / ST2 / fit-1（IL1RL1）和IL-1受体相关蛋白1，最近已被证明是IL-18受体（IL18R1）的组成部分。我们显示，所有基因均朝同一方向转录，而IL1R2则向簇转录。人类重叠群中唯一不存在的家族成员是IL-1受体辅助蛋白基因（IL1RAP），它映射到3q28。版权所有1999 Academic Press。

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