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首页> 外文期刊>Genomics >Polymorphisms in lipogenic genes and milk fatty acid composition in Holstein dairy cattle
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Polymorphisms in lipogenic genes and milk fatty acid composition in Holstein dairy cattle

机译：荷斯坦奶牛脂肪形成基因和牛奶脂肪酸组成的多态性

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摘要

Changing bovine milk fatty acid (FA) composition through selection can decrease saturated FA (SFA) consumption, improve human health and provide a means for manipulating processing properties of milk. Our study determined associations between milk FA composition and genes from triacylglycerol (TAG) biosynthesis pathway. The GC dinucleotide allele of diacylglycerol O-acyltransferase 1:g.10433-10434AA >GC was associated with lower palmitic acid (16:0) concentration but higher oleic (18:1 cis-9), linoleic (18:2 cis-9, cis-12) acid concentrations, and elongation index. Accordingly, the GC dinucleotide allele was associated with lower milk fat percentage and SFA concentrations but higher monounsaturated FA and polyunsaturated FA (PUFA) concentrations. The glycerol-3-phosphate acyltransferase, mitochondrial haplotypes were associated with higher myristoleic acid (14:1 cis-9) concentration and C14 desaturation index. The 1-acylglycerol-3-phosphate acyltransferase 1 haplotypes were associated with higher PUFA and linoleic acid concentrations. The results of this study provide information for developing genetic tools to modify milk FA composition in dairy cattle. (C) 2014 Elsevier Inc. All rights reserved.
机译：通过选择改变牛乳脂肪酸（FA）的成分，可以减少饱和FA（SFA）的消耗，改善人体健康，并提供一种控制牛奶加工性能的手段。我们的研究确定了牛奶FA成分与三酰甘油（TAG）生物合成途径的基因之间的关联。二酰基甘油O-酰基转移酶1：g.10433-10434AA> GC的GC二核苷酸等位基因与较低的棕榈酸（16：0）浓度但较高的油酸（18：1 cis-9），亚油酸（18：2 cis-9）相关，顺式12）的酸浓度和伸长指数。因此，GC二核苷酸等位基因与较低的牛奶脂肪百分比和SFA浓度相关，但与较高的单不饱和FA和多不饱和FA（PUFA）浓度相关。甘油3-磷酸酰基转移酶，线粒体单倍型与较高的肉豆蔻酸（14：1 cis-9）浓度和C14脱饱和指数有关。 1-酰基甘油-3-磷酸酰基转移酶1单倍型与较高的PUFA和亚油酸浓度相关。这项研究的结果为开发遗传工具来修改奶牛的乳FA组成提供了信息。 （C）2014 Elsevier Inc.保留所有权利。

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