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首页> 外文期刊>Genomics >Analysis of reciprocal congenic lines reveals the C3H/HeJ genome to be highly resistant to Apc(Min) intestinal tumorigenesis.
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Analysis of reciprocal congenic lines reveals the C3H/HeJ genome to be highly resistant to Apc(Min) intestinal tumorigenesis.

机译：对等基因的分析表明，C3H / HeJ基因组对Apc（Min）肠道肿瘤发生具有高度抗性。

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摘要

Genetic background affects polyp development in the Multiple intestinal neoplasia (Apc(Min)) mouse model. The Modifier of Min 1 (Mom1) locus accounts for ~50% of the variation in polyp multiplicity. We generated reciprocal congenic lines, such that the recipient C57BL/6J (B6) strain carries a donor C3H/HeJ (C3H) Mom1 allele, and the recipient C3H strain carries a donor B6 Mom1 allele. Hybrid progeny from congenic females mated to B6 Apc(Min/+) males were analyzed. A single C3H Mom1 locus on the B6 background reduced small intestinal polyp numbers by 50% and colon polyp incidence by 66% compared to their susceptible B6 Mom1(S/S)Apc(Min/+) siblings. These findings show that the C3H genome contains a resistant Mom1(R) locus. The reciprocal congenic line, which carries the susceptible B6 Mom1(S) locus on the C3H background, reduced small intestinal polyp numbers by 80% and colon polyp incidence by 95% compared to B6 Mom1(S/S)Apc(Min/+) mice. These data demonstrate that unidentified modifiers in the C3H strain can suppress intestinal polyp multiplicity in Apc(Min/+) mice, and act in the absence of a resistant Mom1(R) locus.
机译：遗传背景会影响息肉在多肠肿瘤（Apc（Min））小鼠模型中的发育。 Min 1（Mom1）基因座的修饰词占息肉多重性变异的〜50％。我们生成了互惠的同系，使得受体C57BL / 6J（B6）株携带供体C3H / HeJ（C3H）Mom1等位基因，并且受体C3H株携带供体B6 Mom1等位基因。分析了来自与B6 Apc（Min / +）雄性交配的同系雌性的杂交后代。与易感的B6 Mom1（S / S）Apc（Min / +）兄弟姐妹相比，B6背景上的单个C3H Mom1基因座使小肠息肉数量减少了50％，结肠息肉发生率减少了66％。这些发现表明，C3H基因组含有抗性的Mom1基因座。与B6 Mom1（S / S）Apc（Min / +）相比，在C3H背景上携带易感性B6 Mom1（S）基因座的互易同系系将小肠息肉数量减少了80％，结肠息肉发生率减少了95％。老鼠。这些数据表明，C3H菌株中未鉴定的修饰物可以抑制Apc（Min / +）小鼠的肠息肉多重性，并在没有抗性Mom1（R）基因座的情况下起作用。

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