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首页> 外文期刊>Genomics >Cloning and mapping of the XRN2 gene to human chromosome 20p11.1-p11.2.
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Cloning and mapping of the XRN2 gene to human chromosome 20p11.1-p11.2.

机译：XRN2基因的克隆并将其定位于人类20p11.1-p11.2染色体。

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摘要

The Dhm1 gene is the mouse homologue of the dhp1(+) gene of Schizosaccharomyces pombe, which is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking, in S. pombe. Complementation analysis showed the Dhm1 gene on a multicopy plasmid can rescue the temperature-sensitivity mutation of dhp1(ts) and the lethality of the dhp1 null mutation. This finding suggests that Dhm1 has a function in mouse similar to that of dhp1(+). The human homologue of this gene, XRN2, has been identified. A 3.6-kb transcript of XRN2 was detected in 16 tissues examined and was more abundant in testis. By radiation hybrid panel mapping, the XRN2 gene was localized to chromosome 20p11.1-p11.2 between markers D20S180 and D20S871. Copyright 1999 Academic Press.
机译：Dhm1基因是粟酒裂殖酵母（Schizosaccharomyces pombe）dhp1（+）基因的小鼠同源物，其在粟酒裂殖酵母中参与同源重组和RNA代谢，例如RNA合成和RNA运输。互补分析表明，多拷贝质粒上的Dhm1基因可以挽救dhp1（ts）的温度敏感性突变和dhp1 null突变的致死性。这一发现表明Dhm1在小鼠中的功能类似于dhp1（+）。该基因XRN2的人类同源物已被鉴定。在检查的16个组织中检测到XRN2的3.6 kb转录本，在睾丸中含量更高。通过辐射杂交板作图，XRN2基因位于标记D20S180和D20S871之间的染色体20p11.1-p11.2。版权所有1999 Academic Press。

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