...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Genomics >Distinct enhancers regulate neural expression of Pax7.
【24h】

Distinct enhancers regulate neural expression of Pax7.

机译：不同的增强子调节Pax7的神经表达。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The murine Pax7 gene has emerged as an important regulator of neural and somite development. It is expressed in discrete domains of the central nervous system, including cranial neural crest, dorsal neural tube, and mesencephalic tectum, pretectum, and base, and at the midbrain-hindbrain boundary. It is also expressed by nasal epithelia and neural crest-derived facial structures. Here, we define the 5' end of the cDNA for murine Pax7 and identify the transcriptional start site. We clarify gene structure and the murine coding sequence, and we define regions of noncoding sequence that are conserved between mice and humans. Using transgenic approaches, we identify upstream and intronic regulatory elements that confer distinct domains of neural expression in the cranial neural crest, facial mesenchyme, mesencephalon, and pontine reticular nucleus. These enhancer regions will be useful for gene expression studies and for the identification of upstream regulators of Pax7 expression.
机译：小鼠Pax7基因已成为神经和体节发育的重要调节器。它在中枢神经系统的离散域中表达，包括颅神经c，背神经管和中脑顶盖，前顶盖和基底，以及在中脑-后脑边界。它也由鼻上皮和神经c衍生的面部结构表达。在这里，我们为鼠Pax7定义了cDNA的5'端，并确定了转录起始位点。我们阐明基因结构和鼠编码序列，并定义在小鼠和人类之间保守的非编码序列区域。使用转基因方法，我们确定了上游和内在调节元件，它们在颅神经c，面部间充质，中脑和桥脑网状核中赋予了不同的神经表达域。这些增强子区域将用于基因表达研究和鉴定Pax7表达的上游调节子。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号