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首页> 外文期刊>Genomics >Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27.
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Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27.

机译：小鼠和人类溶质载体22a3（Slc22a3 / SLC22A3）的克隆确定了小鼠染色体17和人类6q26-q27上三个有机阳离子转运蛋白的保守簇。

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摘要

Here we report the isolation of the mouse and human solute carrier genes Slc22a3/SLC22A3. Slc22a3 is specifically expressed in placenta, but the levels of expression decline toward the end of gestation. A BAC contig spanning the mouse Slc22a3 gene was constructed, and Slc22a3 was mapped between the Igf2r and Plg genes in close association with two additional members of the Slc22a gene family, mouse Slc22a1 and Slc22a2. A partial cDNA sequence of the human SLC22A3 gene was reconstituted from sequenced EST clones. SLC22A3 is expressed in first-trimester and term placenta, but also in skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, and adrenal gland. Using a somatic cell hybrid panel and a human YAC clone, SLC22A3 was mapped to the syntenic region on human chromosome 6q26-q27, between the IGF2R and APO(a)-like genes. SLC22A1 and SLC22A2 localized to the same locus, demonstrating the conservation of the close physical linkage of these three organic cation transporter genes in mouse and human. Copyright 1999 Academic Press.
机译：在这里，我们报告小鼠和人类溶质载体基因Slc22a3 / SLC22A3的分离。 Slc22a3在胎盘中特异性表达，但表达水平在妊娠末期下降。构建了跨越小鼠Slc22a3基因的BAC重叠群，并将Slc22a3定位在Igf2r和Plg基因之间，并与Slc22a基因家族的另外两个成员（小鼠Slc22a1和Slc22a2）紧密相关。从测序的EST克隆中重建了人SLC22A3基因的部分cDNA序列。 SLC22A3在孕早期和足月胎盘中表达，但也在骨骼肌，前列腺，主动脉，肝脏，胎儿肺，唾液腺和肾上腺中表达。使用体细胞杂种面板和人类YAC克隆，将SLC22A3定位到IGF2R和APO（a）样基因之间的人类染色体6q26-q27的同义区域。 SLC22A1和SLC22A2定位于同一基因座，表明这三种有机阳离子转运蛋白基因在小鼠和人类中均保持紧密的物理联系。版权所有1999 Academic Press。

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