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Comparative analysis of microRNA expression in human mesenchymal stem cells from umbilical cord and cord blood

机译：脐带血和脐血中人间充质干细胞中microRNA表达的比较分析

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摘要

Human mesenchymal stem cells (MSCs) derived from both umbilical cord (UC) and cord blood (CB) share similar characteristics, and their differences are largely unknown. Besides the significant difference in cell morphology, differentiation ability and development processes of the two different origin MSCs, a different expression pattern of microRNAs between the two kinds of MSCs was also obtained. By comprehensively annotating the differently expressed global microRNAs (miRNAs), a series of biological pathways were predicted. We found that miRNAs significantly repressed insulin signaling in UCMSCs, while neural related processes were more repressed in CBMSCs. Particularly, TGF-beta and Notch signaling were differently activated in both MSCs, unveiling their distinct angiogenesis potentials. Taken together, this study illustrates that MSCs from UC and CB display distinct properties, which indicates different potentials for clinical usage. (C) 2016 Elsevier Inc. All rights reserved.
机译：源自脐带（UC）和脐带血（CB）的人间充质干细胞（MSC）具有相似的特征，并且它们之间的差异在很大程度上尚不清楚。除了两种不同来源的MSC在细胞形态，分化能力和发育过程上的显着差异外，还获得了两种MSC之间不同的microRNA表达模式。通过全面注释不同表达的全局microRNA（miRNA），可以预测一系列生物学途径。我们发现，miRNA显着抑制UCMSCs中的胰岛素信号传导，而神经相关过程在CBMSCs中更被抑制。特别是，TGF-beta和Notch信号在两个MSC中均被不同地激活，从而揭示了它们独特的血管生成潜力。两者合计，这项研究表明，来自UC和CB的MSC表现出不同的特性，这表明临床使用的潜力不同。 （C）2016 Elsevier Inc.保留所有权利。

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