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首页> 外文期刊>Genomics >Linkage of the locus for canine dewclaw to chromosome 16.
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Linkage of the locus for canine dewclaw to chromosome 16.

机译：犬爪的​​基因座与16号染色体的联系。

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摘要

The canine species, including wolf and jackal, have four digits on the hind limb. It was thought that an extra first digit on the hind limb, named dewclaw, was a hereditary defect. For genetically related canine pedigrees with 73 members with dewclaws, we carried out a genome-wide scan for linkage with microsatellites. With an assumption of autosomal dominant mode of inheritance, significant linkages were detected for the markers on canine chromosome 16. The maximum two-point lod score of 20.76 was obtained for the REN85M08/REN85N14 markers at a recombination fraction of 0.00. For efficient analysis of linkage, a revised order of the chromosomal markers was established by assigning all the existing markers from the previous linkage and radiation hybrid maps. A chromosome-wide haplotype analysis revealed the location of the dewclaw locus within a few centimorgan intervals delimited by the UCMCF12 and CXX876 markers. Canine chromosome 16 is known to have syntenic relationships with human chromosomes 4q, 7q, and 8p.
机译：犬种，包括狼和jack狼，在后肢上有四个数字。有人认为后肢上的另一个第一手指，称为露爪，是遗传缺陷。对于有73个狼爪成员的遗传犬科，我们进行了全基因组扫描，以查找与微卫星的连锁关系。假定为常染色体显性遗传方式，则检测到犬16号染色体上标记的显着连锁。在0.00重组分数下，REN85M08 / REN85N14标记的最大两点lod得分为20.76。为了有效分析连锁，通过分配先前连锁和辐射杂交图谱中的所有现有标记，建立了染色体标记的修订顺序。整个染色体的单倍型分析揭示了在由UCMCF12和CXX876标记界定的几个厘摩间隔内的露爪基因座的位置。犬16号染色体与人类4q，7q和8p染色体具有同系关系。

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