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首页> 外文期刊>Genomics >Resequencing diverse Chinese indigenous breeds to enrich the map of genomic variations in swine
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Resequencing diverse Chinese indigenous breeds to enrich the map of genomic variations in swine

机译：对不同的中国本土品种进行重新测序，以丰富猪的基因组变异图

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摘要

To enrich the map of genomic variations in swine, we randomly sequenced 13 domestic and wild individuals from China and Europe. We detected approximately 28.1 million single nucleotide variants (SNVs) and 3.6 million short insertions and deletions (INDELs), of which 2,530,248 SNVs and 3,456,626 INDELs were firstly identified compared with dbSNP 143. Moreover, 208,687 SNVs and 24,161 INDELs were uniquely observed in Chinese pigs, potentially accounting for phenotypic differences between Chinese and European pigs. Furthermore, significantly high correlation between SNV and INDEL was witnessed, which indicated that these two distinct variants may share similar etiologies. We also predicted loss of function genes and found that they were under weaker evolutionary constraints. This study gives interesting insights into the genomic features of the Chinese pig breeds. These data would be useful in the establishment of high-density SNP map and would lay a foundation for facilitating pig functional genomics study. (C) 2015 Elsevier Inc. All rights reserved.
机译：为了丰富猪的基因组变异图谱，我们对来自中国和欧洲的13个家养和野生个体进行了随机测序。我们检测到约2810万个单核苷酸变体（SNV）和360万个短插入和缺失（INDEL），其中与dbSNP 143相比，首次发现了2,530,248个SNV和3,456,626个INDEL。此外，在中国猪中独特地观察到208,687个SNV和24,161个INDEL。 ，可能解释了中国和欧洲猪之间的表型差异。此外，见证了SNV与INDEL之间的显着高度相关性，这表明这两个不同的变体可能具有相似的病因。我们还预测了功能基因的丢失，并发现它们处于较弱的进化约束之下。这项研究对中国猪品种的基因组特征提供了有趣的见解。这些数据将有助于建立高密度SNP图谱，并为促进猪功能基因组学研究奠定基础。 （C）2015 Elsevier Inc.保留所有权利。

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