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Discrepancies between the K-ras mutational status of primary colorectal cancers and corresponding liver metastases are found in codon 13

机译：原发性结直肠癌的K-ras突变状态与相应的肝转移之间的差异在13号密码子中发现

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摘要

K-ras mutation status has remained elusive in the metastatic liver tumors of colorectal cancer (CRC) in contrast to the primary CRC tumors. In this study, K-ras mutational status of the primary and corresponding liver metastatic tumors was investigated in the 43 CRC patients. Codons 12 and 13 of K-rag were directly sequenced, and a K-ras mutation was evident in 17 cases (39.5%). In 6 cases, the K-ras mutation was evident only in the liver metastasis, but not in the primary CRC, where the mutation was found in codon 13. This discrepancy between primary and metastatic lesions with regard to codon 13 of the K-ras gene may explain the clinical discrepancy of EGFR antibody therapy. In conclusion, the current data may lead to the development of personalized medicine for recurrent CRC, although further validation study is still required. (C) 2015 Elsevier Inc. All rights reserved.
机译：与原发性CRC肿瘤相比，K-ras突变状态在结直肠癌（CRC）的转移性肝肿瘤中仍然难以捉摸。在这项研究中，调查了43例CRC患者的原发性和相应肝转移性肿瘤的K-ras突变状态。直接对K-rag的密码子12和13进行测序，在17例中（39.5％）明显出现K-ras突变。在6例病例中，K-ras突变仅在肝转移中很明显，而在原发性CRC中则没有，后者在第13位密码子中发现。在原发性和转移性病变之间，K-ras的第13位密码子存在差异。该基因可能解释了EGFR抗体治疗的临床差异。总之，尽管仍需要进一步的验证研究，但目前的数据可能会导致针对复发性CRC的个性化药物的开发。 （C）2015 Elsevier Inc.保留所有权利。

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