• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Genomics >Integrated analysis of mRNA and miRNA expression in response to interleukin-6 in hepatocytes
【24h】

Integrated analysis of mRNA and miRNA expression in response to interleukin-6 in hepatocytes

机译：综合分析肝细胞中白细胞介素6对mRNA和miRNA表达的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The expression of plasma proteins changes dramatically as a result of cytokine induction, particularly interleukin-6, and their levels are used as clinical markers of inflammation. miRNAs are important regulators of gene expression and play significant roles in many inflammatory diseases and processes. The interactions between miRNAs and the genes that they regulate during the acute phase response have not been investigated. We examined the effects of IL-6 stimulation on the transcriptome and miRNome of human and mouse primary hepatocytes and the HepG2 cell line. Using an integrated analysis, we identified differentially expressed miRNAs whose seed sequences are significantly enriched in the 3' untranslated regions of differentially expressed genes, many of which are involved in inflammation-related pathways. Our finding that certain miRNAs may de-repress critical acute phase proteins within acute timeframes has important biological and clinical implications. (C) 2015 Elsevier Inc. All rights reserved.
机译：血浆蛋白的表达由于细胞因子的诱导而发生了巨大变化，特别是白介素6的诱导，其水平被用作炎症的临床标志。 miRNA是基因表达的重要调节剂，并在许多炎症性疾病和过程中发挥重要作用。尚未研究miRNA及其在急性期反应中调控的基因之间的相互作用。我们检查了IL-6刺激对人和小鼠原代肝细胞和HepG2细胞系的转录组和miRNome的影响。使用综合分析，我们确定了差异表达的miRNA，其种子序列明显富集于差异表达基因的3'非翻译区，其中许多与炎症相关的途径有关。我们的发现某些miRNA可能在急性时限内抑制重要的急性期蛋白具有重要的生物学和临床意义。 （C）2015 Elsevier Inc.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号