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Identification of G protein-coupled receptors in the pea aphid, Acyrthosiphon pisum

机译:豌豆蚜虫中的G蛋白偶联受体的鉴定

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GPCRs play crucial roles in the growth, development and reproduction of organisms. In insects, a large number of GPCRs have been reported for Holometabola but not Hemimetabola. The recently sequenced pea aphid genome provides us with the opportunity to analyze the evolution and potential functions of GPCRs in Hemimetabola. 82 GPCRs were identified from the representative model hemimetabolous insect Acyrthosiphon pisum, 37 of which have ESTs evidence, and 73 are annotated for the first time. A striking difference between A. pisum, Drosophila melanogaster and Tribolium castaneum is the duplication of the kinin and SIFamide receptors in A. pisum. Another divergence is the loss of the sulfakinin receptor in A. pisum. These duplications/losses are likely involved in the osmoregulation, reproduction and energy metabolism of A. pisum. Moreover, this work will promote functional analyses of GPCRs in A. pisum and may advance new drug target discovery for biological control of the aphid.
机译:GPCR在生物的生长,发育和繁殖中起着至关重要的作用。在昆虫中,已报道了大隐花蛾的大量GPCR,而未报道半隐花蛾的GPCR。最近测序的豌豆蚜基因组为我们提供了机会,可以分析Hemimetabola中GPCR的进化和潜在功能。从具有代表性的半代谢昆虫小蚜虫中鉴定出82个GPCR,其中37个具有EST证据,并且首次注释了73个。 Pi。A. pisum,果蝇果蝇和Tribolium castaneum之间的一个显着差异是Pi。A. pisum中激肽和SIFamide受体的重复。另一个分歧是pisum中的sulfakinin受体丢失。这些重复/丢失可能参与了豌豆曲霉的渗透调节,繁殖和能量代谢。此外,这项工作将促进pisum中的GPCRs的功能分析,并可能促进对蚜虫进行生物防治的新药靶标发现。

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