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首页> 外文期刊>Biogenic amines >Effect of indisetron, a 5-HT3_/HT_4 ceptor antagonist, on paroxetine- induced emesis in suncus murinus
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Effect of indisetron, a 5-HT3_/HT_4 ceptor antagonist, on paroxetine- induced emesis in suncus murinus

机译：5-HT3_ / HT_4受体拮抗剂Indisetron对帕罗西汀诱发的太阳sun呕吐的作用

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摘要

Our study of the mechanism of paroxetine-induced nausea and vomitingindicated the following: 1.The occurrence of paroxetine-induced emesis was dose-dependent. Weclarified that shrews are a useful animal model for paroxetine-inducedemesis. 2.As indisetron tended to inhibit paroxetine-induced emesis, it was pre-sumed that this emesis is associated with both 5-HT_3and 5-HT4receptors.Moreover, since orally administered indisetron inhibited paroxetine-indu-ced emesis more effectively than intraperitoneally injected indisetron, theintestinal tract luminal mucous membrane might play an important rolein the occurrence of paroxetine-induced emesis. These findings suggestthat during the initial phase of paroxetine administration, combiningparoxetine with an 5-HT_3and 5-HT_4receptor antagonist may increase thepatient's QOL
机译：我们对帕罗西汀引起的恶心和呕吐的机制研究表明：1.帕罗西汀引起的呕吐的发生与剂量有关。我们阐明了sh是帕罗西汀诱导呕吐的有用动物模型。 （2）由于indisetron倾向于抑制帕罗西汀引起的呕吐，因此推测该呕吐与5-HT_3和5-HT4受体有关。 ，肠腔粘膜可能在帕罗西汀引起的呕吐的发生中起重要作用。这些发现表明，在帕罗西汀给药的初始阶段，将帕罗西汀与5-HT_3和5-HT_4受体拮抗剂联合使用可能会增加患者的QOL

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