Tissue Specific Choice of Ranimustine and Nimustine onthe Basis of Polyamine Level

Satoru W_(ATANABE); SumikaN_(AGASE); ShoichiSATO; Seitaro OHKUMA

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Tissue Specific Choice of Ranimustine and Nimustine onthe Basis of Polyamine Level

机译：基于多胺水平的拉尼莫司汀和尼莫斯汀的组织特异性选择

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摘要

The aim of this study improves the chemotherapeutic effects of3- [4-amino-2-methyl-5-pyrimidinyl] methyl]-1- (2-chloroethyl)-1-nitrosoureahydrochloride (nimustine: ACNU) and methyl 643 - (2-chloroethyl)-3 -nitrosoureido] -6 -deoxy-alpha-D -glucopyranoside (ranimustine: MCNU)by choosing tissue specific treatment on the basis of polyamine level in eachcancer-bearing host tissue induced by the drugs. The effects of these anti-cancer drugs on body weight, some organ weights and the concentrations ofputrescine, spermidine and spermine in 14 different tissues were examined inrats that had been given the drugs for five consecutive days.

机译：这项研究的目的是提高3- [4-氨基-2-甲基-5-嘧啶基]甲基] -1-（2-氯乙基）-1-亚硝基脲盐酸盐（尼莫斯汀：ACNU）和甲基643-（2- （氯乙基）-3-亚硝基脲基] -6-脱氧-α-D-吡喃葡萄糖苷（ranimustine：MCNU），根据药物诱导的每个带有癌的宿主组织中的多胺水平选择组织特异性治疗方法。连续五天给老鼠喂食了这些抗癌药，它们对14种不同组织的体重，一些器官重量以及腐胺，亚精胺和精胺的浓度产生了影响。

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来源
《Biogenic amines》 |2008年第6期|共12页
作者
Satoru W_(ATANABE); SumikaN_(AGASE); ShoichiSATO; Seitaro OHKUMA;
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原文格式 PDF
正文语种 eng
中图分类 582LB077;
关键词
polyamine; ranimustine; nimustine; cancer; rat;

机译：多胺;拉尼莫司汀;尼莫斯汀;癌症;大鼠;

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专利

1. Tissue Specific Choice of Ranimustine and Nimustine onthe Basis of Polyamine Level [J] . Satoru W_(ATANABE), SumikaN_(AGASE), ShoichiSATO, Biogenic amines . 2008,第6期

机译：基于多胺水平的拉尼莫司汀和尼莫斯汀的组织特异性选择
2. Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion. [J] . Dogan A, Rao AM, Hatcher J, Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 1999,第2期

机译：MDL 72527（一种多胺氧化酶的特异性抑制剂）对暂时性大脑中动脉闭塞后大鼠脑水肿，缺血性损伤量和组织中多胺水平的影响。
3. Effective Anticancer Drug and Food Choices Based on Polyamine Levels Cancer Tissues [J] . Satoru Watanabe, Sumika Nagase, Shoichi Sato, Current drug therapy . 2009,第3期

机译：基于多胺水平的癌组织的有效抗癌药物和食物选择
4. Prostate Tissue Classification Based on Prostate-Specific Antigen Levels and Mitochondrial DNA Copy Number Using Artificial Neural Network [C] . Lemana Spahic, Sabahudin Cordic International Conference on Medical and Biological Engineering . 2020

机译：基于前列腺特异性抗原水平和使用人工神经网络的线粒体DNA拷贝数的前列腺组织分类
5. Quantification of transcript levels of CHS genes leads to the discovery of siRNA mediated tissue specific gene silencing [D] . Tuteja, Jigyasa Harnit 2004

机译：CHS基因转录水平的定量导致发现siRNA介导的组织特异性基因沉默
6. Spatial and Temporal Distribution of Polyamine Levels and Polyamine Anabolism in Different Organs/Tissues of the Tobacco Plant. Correlations with Age Cell Division/Expansion and Differentiation [O] . Konstantinos A. Paschalidis, Kalliopi A. Roubelakis-Angelakis 2005

机译：烟草植物不同器官/组织中多胺水平和多胺代谢的时空分布。与年龄细胞分裂/扩增和分化的相关性
7. Effects of MDL 72527, a Specific Inhibitor of Polyamine Oxidase, on Brain Edema, Ischemic Injury Volume, and Tissue Polyamine Levels in Rats After Temporary Middle Cerebral After Occlusion [O] . Aclan Dogan, A. Muralikrishna Rao, James Hatcher, 1999

机译：MDL 72527，多胺氧化酶特异性抑制剂对大鼠脑水肿，缺血性体积和组织多胺水平闭塞后闭塞后大鼠
8. Cell Differentiation, Alterations in Polyamine Levels, and Specific Binding of Phorbol Diesters in Cultured Human Cells [R] . Huberman, E., Weeks, C., Solanki, V., 1980

机译：细胞分化，多胺水平的改变以及phorbol Diesters在培养的人类细胞中的特异性结合

Tissue Specific Choice of Ranimustine and Nimustine onthe Basis of Polyamine Level

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