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首页> 外文期刊>Gait & posture >Relationship between mild cognitive impairment and falls in older people with and without Parkinson's disease: 1-Year Prospective Cohort Study.
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Relationship between mild cognitive impairment and falls in older people with and without Parkinson's disease: 1-Year Prospective Cohort Study.

机译：有和没有帕金森氏病的老年人轻度认知障碍与跌倒的关系：1年前瞻性队列研究。

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We conducted a 12-month longitudinal cohort study of 102 older people without dementia (52 Parkinson's Disease [PD]; 50 age- and sex-matched controls) to determine (1) if mild cognitive impairment predicts falls in older people with or without PD and (2) how baseline falls, a history of freezing and Hoehn and Yahr stage affected the association between cognitive impairment and multiple falls in PD patients. Cognitive impairment was defined as the sum of impairments on the caregiver-rated Clinical Dementia Rating Scale (CCDRSum>0). Overall the mean age (SD) was 71.5 (4.7) years, 42% were women, 26% had fallen and 14% had cognitive impairment at baseline. Thirty-one percent (15/52) of PD patients vs 12% (6/50) of controls fell more than once during 12-month follow-up, p=0.04. When combined in a 2-predictor model for the entire cohort, the adjusted odds ratios [aOR] for falling were significantly increased for cognitive impairment at baseline (aOR: 4.8, 95% CI: 1.3-18.2) and prior falls (aOR: 7.4, 95% CI: 2.4-22.3). The overall accuracy of the model was 82%, with low sensitivity of 19% but high specificity of 99%. In the PD subgroup, the overall accuracy of the same prediction model was 79%, with much better sensitivity of 73% but a lower specificity of 81%. We conclude that mild cognitive impairment might contribute to falls risk beyond conventional risk factors in older people with and without PD.
机译：我们对102位无痴呆症的老年人（52帕金森氏病[PD]; 50位年龄和性别匹配的对照组）进行了为期12个月的纵向队列研究，以确定（1）轻度认知障碍是否预示着有或没有PD的老年人的跌倒（2）基线下降，冻结的病史以及Hoehn和Yahr阶段如何影响PD患者认知障碍与多次跌倒之间的关联。认知障碍定义为照护者评定的《临床痴呆症评分量表》（CCDRSum> 0）的损伤总和。总体平均年龄（SD）为71.5（4.7）岁，女性为42％，跌落为26％，基线时认知障碍为14％。在12个月的随访中，PD患者的31％（15/52）与对照组的12％（6/50）下降了一次以上，p = 0.04。当在整个队列的2-预测模型中组合时，基线时的认知障碍（aOR：4.8，95％CI：1.3-18.2）和先前跌倒（aOR：7.4）的跌倒调整比值比[aOR]显着增加，95％CI：2.4-22.3）。该模型的总体准确性为82％，低灵敏度为19％，高特异性为99％。在PD亚组中，同一预测模型的总体准确度为79％，灵敏度更高，为73％，但特异性更低，为81％。我们得出的结论是，患有或不患有PD的老年人，轻度认知障碍可能会导致其风险降至常规风险因素之外。

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