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首页> 外文期刊>Genes and Development: a Journal Devoted to the Molecular Analysis of Gene Expression in Eukaryotes, Prokaryotes, and Viruses >New ways to meet your (3') end oligouridylation as a step on the path to destruction.
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New ways to meet your (3') end oligouridylation as a step on the path to destruction.

机译：满足您（3'）要求的新方法将寡糖化终止，作为迈向破坏之路的一步。

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摘要

Messenger RNA degradation is a vital contributor to the control of gene expression that generally involves removal of a poly(A) tail in both prokaryotes and eukaryotes.In a thought-provoking study in this issue of Genes & Development, Mullen and Marzluff (2008) present data supporting a novel mechanism of mRNA decay. They discovered that histone mRNAs, which are unique in that they are never polyadenylated in mammalian cells, degrade by a cell cycle-regulated mechanism that involves addition of a short oligo(U) tail at the 3' end. Interestingly, this oligo(U) tract is recognized by the Lsm1-7 complex, which then appears to feed the transcript into the standard mRNA decay pathways. These findings are exciting because they invoke parallels with prokaryotic mRNA decay, which requires polyadenylationimmediately prior to degradation and involves an Lsm homolog, Hfq. Moreover, recent studies have identified other oligouridylated RNAs and several poly(U) polymerases, implying that this may be a more widespread mechanism for turnover of RNA.
机译：信使RNA的降解是控制基因表达的重要因素，通常涉及去除原核生物和真核生物中的poly（A）尾巴.Mullen和Marzluff（2008）在本期《基因与发展》的发人深省的研究中。目前的数据支持mRNA衰减的新机制。他们发现，组蛋白mRNA的独特之处在于它们从未在哺乳动物细胞中被聚腺苷酸化，并通过细胞周期调控的机制降解，该机制涉及在3'端添加一条短的oligo（U）尾巴。有趣的是，该寡核苷酸（U）被Lsm1-7复合物识别，然后似乎将转录物输入标准的mRNA衰变途径。这些发现令人兴奋，因为它们与原核mRNA衰变具有相似性，这要求在降解之前立即进行聚腺苷酸化，并涉及一个Lsm同源物Hfq。而且，最近的研究已经鉴定出其他寡聚尿苷酸化的RNA和几种poly（U）聚合酶，这暗示这可能是RNA转换的更广泛的机制。

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