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首页> 外文期刊>Genetics Research >Non-stringent tissue-source requirements for BMP ligand expression in regulation of body size in Caenorhabditis elegans.
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Non-stringent tissue-source requirements for BMP ligand expression in regulation of body size in Caenorhabditis elegans.

机译：秀丽隐杆线虫体内BMP配体表达的严格组织来源要求。

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In Caenorhabditis elegans, the Bone Morphogenetic Protein (BMP)-related ligand Dpp- and BMP-like-1 (DBL-1) regulates body size by promoting the larval and adult growth of the large epidermal syncytium hyp7 without affecting cell division. This system provides an excellent model for dissecting the growth-promoting activities of BMP ligands, since in this context the growth and differentiation functions of DBL-1 are naturally uncoupled. dbl-1 is expressed primarily in neurons and the DBL-1 ligand signals to its receptors and Smad signal transducers in the target tissue of the epidermis. The requirements constraining the source(s) of DBL-1, however, have not previously been investigated. We show here that dbl-1 expression requirements are strikingly relaxed. Expression in non-overlapping subsets of the endogenous expression pattern, as well as ectopic expression, can provide sufficient levels of activity for rescue of the small body size of dbl-1 mutants. By analysing dbl-1 expression levels in transgenic strains with different degrees of rescue, we corroborate the model that DBL-1 is a dose-dependent regulator of growth. We conclude that, for body size regulation, the site of expression of dbl-1 is less important than the level of expression.Digital Object Identifier http://dx.doi.org/10.1017/S0016672311000310
机译：在秀丽隐杆线虫中，骨形态发生蛋白（BMP）相关配体Dpp-和BMP-like-1（DBL-1）通过促进大型表皮合胞体hyp7的幼虫和成年生长来调节体重。而不影响细胞分裂。该系统为剖析BMP配体的生长促进活性提供了一个极好的模型，因为在这种情况下，DBL-1的生长和分化功能自然是不偶联的。 dbl-1 主要在神经元中表达，DBL-1配体向表皮靶组织中的受体和Smad信号转导子发出信号。但是，以前没有研究过限制DBL-1来源的要求。我们在这里显示 dbl-1 表达式要求显着放宽。在内源性表达模式的非重叠子集中的表达以及异位表达可提供足够水平的活性，以拯救 dbl-1 突变体的小体型。通过分析具有不同拯救程度的转基因菌株中的 dbl-1 表达水平，我们证实了DBL-1是剂量依赖性生长调节剂的模型。我们得出的结论是，对于身体大小的调节， dbl-1 的表达位点不如表达水平重要。数字对象标识符http://dx.doi.org/10.1017/S0016672311000310

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