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ADZE: a rarefaction approach for counting alleles private to combinations of populations

机译：ADZE：一种稀有方法，用于对种群组合中的私人等位基因进行计数

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MOTIVATION: Analysis of the distribution of alleles across populations is a useful tool for examining population diversity and relationships. However, sample sizes often differ across populations, sometimes making it difficult to assess allelic distributions across groups. RESULTS: We introduce a generalized rarefaction approach for counting alleles private to combinations of populations. Our method evaluates the number of alleles found in each of a set of populations but absent in all remaining populations, considering equal-sized subsamples from each population. Applying this method to a worldwide human microsatellite dataset, we observe a high number of alleles private to the combination of African and Oceanian populations. This result supports the possibility of a migration out of Africa into Oceania separate from the migrations responsible for the majority of the ancestry of the modern populations of Asia, and it highlights the utility of our approach to sample size correction in evaluating hypotheses about population history. AVAILABILITY: We have implemented our method in the computer pro-gram ADZE, which is available for download at http://rosenberglab.bioinformatics.med.umich.edu/adze.html.
机译：动机：分析人群中等位基因的分布是检查人群多样性和关系的有用工具。但是，样本量通常因人群而异，有时使评估群体之间的等位基因分布变得困难。结果：我们引入了一种通用稀疏方法来对种群组合中的私人等位基因进行计数。我们的方法评估了在每个种群中发现但在所有其余种群中均不存在的等位基因的数量，并考虑了每个种群中大小相等的子样本。将这种方法应用于世界范围内的人类微卫星数据集，我们观察到了非洲和大洋洲种群组合中大量的等位基因。这一结果支持了从非洲迁移到大洋洲的可能性，而不是亚洲现代人口大多数祖先的迁移原因，它突出了我们的样本量校正方法在评估有关人口历史假设中的效用。可用性：我们已经在计算机程序ADZE中实现了我们的方法，该程序可从http://rosenberglab.bioinformatics.med.umich.edu/adze.html下载。

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