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首页> 外文期刊>British Journal of Clinical Pharmacology >Changes in antipsychotic drug prescribing by general practitioners in the United Kingdom from 1991 to 2000: a population-based observational study.
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Changes in antipsychotic drug prescribing by general practitioners in the United Kingdom from 1991 to 2000: a population-based observational study.

机译：1991年至2000年，英国全科医生开出的抗精神病药物处方的变化：一项基于人群的观察性研究。

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AIM: To estimate changes in the frequency of use of various antipsychotic drugs in the UK from 1991 to 2000 and to relate these changes to patients' characteristics. METHODS: We conducted a population-based observational study using data from general practices that contribute information to the General Practice Research Database (GPRD). The study population comprised men and women 10-99 years old. We estimated annual use, first-time use, duration of use and, in a sample of 200 patients, indications for use of various antipsychotic drugs, and we observed how these measures had changed over the past decade. RESULTS: The annual use of antipsychotic drugs increased from 10.5 per thousand in 1991 to 12.2 per thousand in 2000, an overall increase of 16%. The increase was greater in men (25.2%) than women (2.7%). At the same time, the rate of new use of antipsychotic drugs was stable in men and decreased by 21% in women. The difference between patterns of annual use and rates of new use is attributable to theincreasing average annual duration of treatment in both men and women during the past decade. Thioridazine, which the UK Committee on the Safety of Medicines (CSM) recently recommended should be used only for second-line treatment of schizophrenia in adults, was the most commonly prescribed antipsychotic throughout the study period. Its use increased as a proportion of all antipsychotic drug use from 1991 to 2000 in men and women aged 10-69 years, but decreased in older users. More than half of all first-time use of antipsychotic drugs in the sample of patients we evaluated was for treatment of depression, anxiety states, and panic disorders, while less than 10% was for treatment of schizophrenia and other psychoses. CONCLUSION: The use of antipsychotic drugs has increased in the UK during the past decade, primarily due to increased average annual duration of use rather than higher rates of new use. Most antipsychotic drug use appears to have been prescribed to treat nonpsychotic disorders. It will be of interest to see whether the use of thioridazine, which was the most widely prescribed antipsychotic during 1991-2000, decreases during the next decade in response to the recent CSM recommendation.
机译：目的：评估1991年至2000年英国各种抗精神病药物使用频率的变化，并将这些变化与患者的特征联系起来。方法：我们使用来自一般实践的数据进行了基于人群的观察研究，这些数据为一般实践研究数据库（GPRD）提供了信息。研究人群包括10-99岁的男性和女性。我们估算了年度使用量，首次使用量，使用期限以及200名患者的样本中使用各种抗精神病药物的适应症，并观察了这些措施在过去十年中的变化。结果：抗精神病药物的年使用量从1991年的每千人10.5增加到2000年的每千人12.2，增加了16％。男性（25.2％）比女性（2.7％）的增长更大。同时，男性抗精神病药的新使用率稳定，女性减少了21％。年度使用模式和新使用率之间的差异是由于过去十年中男女平均每年的治疗持续时间增加。英国药物安全委员会（CSM）最近建议使用的噻吩达嗪只能用于成人精神分裂症的二线治疗，是整个研究期间最常用的抗精神病药。从1991年至2000年，年龄在10-69岁之间的男性和女性，其使用量在所有抗精神病药物使用量中所占的比例有所增加，但在老年用户中则有所减少。在我们评估的患者样本中，所有首次使用抗精神病药的患者中有一半以上用于治疗抑郁症，焦虑症和恐慌症，而用于精神分裂症和其他精神病的患者不足10％。结论：在过去的十年中，抗精神病药的使用在英国有所增加，这主要是由于平均每年的使用年限增加，而不是新的使用率增加。多数抗精神病药物的使用似乎已开处方用于治疗非精神病性疾病。有趣的是，根据最近的CSM建议，在接下来的十年中，使用thioridazine（在1991-2000年间最广泛使用的抗精神病药）是否减少。

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