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首页> 外文期刊>Gut: Journal of the British Society of Gastroenterology >The window hypothesis: Haemodynamic and non-haemodynamic effects of β-blockers improve survival of patients with cirrhosis during a window in the disease
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The window hypothesis: Haemodynamic and non-haemodynamic effects of β-blockers improve survival of patients with cirrhosis during a window in the disease

机译：窗口假说：β受体阻滞剂的血液动力学和非血液动力学作用可改善肝硬化患者在疾病窗口期间的存活率

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摘要

Cirrhosis is one of the most frequent and severe chronic-diseases worldwide. In the initial stages it has few or no symptoms, but advanced stages of cirrhosis are characterised by reduced liver function, complications due to portal hypertension and neuroendocrine abnormalities with increased activity of the sympathetic nervous system (SNS) and renin-aldoste-rone axis. The prognosis is severe, with an increasing frequency of complications including variceal bleeding, ascites and spontaneous infections with subsequent development of hepatic encephalopathy and hepatorenal syndrome. More than one-third of patients diagnosed with cirrhosis develop oesophageal varices within 3 years after the diagnosis is made.
机译：肝硬化是世界上最常见，最严重的慢性病之一。在最初阶段，它几乎没有或没有任何症状，但是肝硬化的晚期阶段的特征是肝功能降低，门脉高压引起的并发症和神经内分泌异常，以及交感神经系统（SNS）和肾素-醛固酮隆起轴的活动增加。预后很严重，并发症的发生频率不断增加，包括静脉曲张破裂出血，腹水和自发感染，随后发展为肝性脑病和肝肾综合征。在做出诊断后的三年内，超过三分之一的被诊断为肝硬化的患者会出现食管静脉曲张。

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