• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Faraday discussions >Terahertz pulsed imaging and spectroscopy for biomedical and pharmaceutical applications
【24h】

Terahertz pulsed imaging and spectroscopy for biomedical and pharmaceutical applications

机译：用于生物医学和制药应用的太赫兹脉冲成像和光谱学

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Terahertz (THz) radiation lies between the infrared and microwave regions of the electromagnetic spectrum. Advances in THz technology have opened up many opportunities in this scientifically and technologically important spectroscopic region. The THz frequency range excites large amplitude vibrational modes of molecules as well as probing the weak interactions between them. Here we describe two techniques that utilize THz radiation, terahertz pulsed imaging (TPI) and terahertz pulsed spectroscopy (TPS). Both have a variety of possible applications in biomedical imaging and pharmaceutical science. TPI, a non-invasive imaging technique, has been used to image epithelial cancer ex vivo and recently in vivo. The diseased tissue showed a change in absorption compared to normal tissue, which was confirmed by histology. To understand the origins of the differences seen between diseased and normal tissue we have developed a TPS system. TPS has also been used to study solids of interest in the pharmaceutical industry. One particularly interesting example is ranitidine hydrochloride, which is used in treatment of stomach ulcers. Crystalline ranitidine has two polymorphic forms known as form 1 and form 2. These polymorphs have the same chemical formula but different crystalline structure that give rise to different physiochemical properties of the material. Using TPS it is possible to rapidly distinguish between the two polymorphic forms.
机译：太赫兹（THz）辐射位于电磁频谱的红外和微波区域之间。太赫兹技术的进步为这一在科学和技术上十分重要的光谱领域打开了许多机会。太赫兹频率范围激发了分子的大振幅振动模式并探究了它们之间的弱相互作用。在这里，我们描述了两种利用太赫兹辐射的技术，太赫兹脉冲成像（TPI）和太赫兹脉冲光谱（TPS）。两者在生物医学成像和药物科学中都有多种可能的应用。 TPI，一种非侵入性成像技术，已被用于离体和最近体内成像上皮癌。与正常组织相比，患病组织显示出吸收变化，这在组织学上得到了证实。为了了解患病组织与正常组织之间差异的起源，我们开发了TPS系统。 TPS也已用于研究制药行业中感兴趣的固体。一个特别有趣的例子是盐酸雷尼替丁，其用于治疗胃溃疡。雷尼替丁的结晶具有两种多晶型物，分别称为晶型1和晶型2。这些多晶型物具有相同的化学分子式但具有不同的晶体结构，从而导致材料的不同物理化学性质。使用TPS，可以快速区分两种多态形式。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号