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Terahertz pulsed imaginga nd spectrosocopy for biomedical and pharmaceutical applications

机译：太赫兹脉冲成像和光谱学用于生物医学和制药应用

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Terahertz (THz) radiation lies between the infrared and microwave regions of the electromagnetic spectrum.Advancesin THz technology have opened up many opportunities in this scientifically and technologically important spectroscopic region.The THz frequency range excites large amplitude vibrational modes of molecules as well as probing the weak interactions between them.Here we describe two techniques taht utilize THz radiation,terahertz pulsed imaging (TPI) and terahertz pulsed spectroscopy (TPS).Both have a variety of possible applications in biomedical imaging and pharmaceutical science.TPI,a non-invasive imaging technique,has been used to image epithelial cancer ex vivo and recently in vivo.The diseased tissues showed a change in absorption compared ot normal tissue,which was confirmed by histology.To understand the origins of the differences seen between diseased and normal tisse we have developed a TPS system.TPS has also been used to study solids of interest in the pharmaceutical industry.One particularly interesting example is ranitidine hydrochloride,which is used in treatment of stomach ulcers.Crystalline ranitidine has two polymorphic forms known as form 1 and form 2.These polymorphs have the same chemical formula but different crystalline structure that give rise to different physiochemical properties of the material.Using TPS it is possible to rapidly distinguish between the two polymorphic forms.
机译：太赫兹（THz）辐射位于电磁频谱的红外和微波区域之间.THz技术的进步为这一在科学和技术上很重要的光谱区域开辟了许多机会.THz频率范围激发了分子的大振幅振动模式并探测了分子太赫兹脉冲成像（TPI）和太赫兹脉冲光谱（TPS）是这两种利用太赫兹辐射的技术。在生物医学成像和制药科学中，这两种技术都有多种可能的应用。该技术已被用于离体和近期体内成像的上皮癌。病变组织与正常组织相比显示出吸收变化，这在组织学上得到了证实。要了解病变组织与正常组织之间的差异，我们有开发了TPS系统。TPS也已用于研究药物中感兴趣的固体在工业中，一个特别有趣的例子是盐酸雷尼替丁，它用于治疗胃溃疡。结晶雷尼替丁具有两种多晶型形式，分别称为晶型1和晶型2，这些多晶型物具有相同的化学式，但晶体结构不同，导致晶型不同使用TPS可以快速区分两种多晶型物。

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