...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Growth hormone and IGF research: Official journal of the Growth Hormone Research Society and the International IGF Research Society >Pregnancy-induced increase in circulating IGF-I is associated with progression of diabetic retinopathy in women with type 1 diabetes.
【24h】

Pregnancy-induced increase in circulating IGF-I is associated with progression of diabetic retinopathy in women with type 1 diabetes.

机译：妊娠引起的循环IGF-1升高与1型糖尿病女性糖尿病性视网膜病变的进展有关。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: To evaluate the influence of Insulin-like Growth factor-I (IGF-I) and Placental Growth Hormone (GH) on progression of diabetic retinopathy during pregnancy in women with type 1 diabetes. DESIGN: Observational study of 88 consecutive pregnant women with type 1 diabetes for median 16.5 years (range 1-36) and HbA(1c) 6.6% (5.2-10.5) in early pregnancy. At 8, 14, 21, 27 and 33 weeks blood samples were drawn for measurement of IGF-I, placental GH and Hemoglobin A(1c) (HbA(1c)) and blood pressure was recorded. Fundus photography was performed at 8 and 27 weeks. Diabetic retinopathy was classified in five stages. Progression was defined as deterioration of at least one stage of diabetic retinopathy and/or development of macular edema on at least one eye. RESULTS: Placental GH and IGF-I levels increased throughout pregnancy and new onset or progression of diabetic retinopathy occurred in 22 (25%). A steeper increase in women with progression of diabetic retinopathy resulted in higher IGF-I levels at 27 weeks (p=0.01) and 16% higher IGF-I levels throughout pregnancy (p=0.02) compared with women without progression while similar levels of placental GH (p=0.58) and HbA(1c) (p=0.85) were observed throughout pregnancy. In a multivariate logistic regression analysis, progression of diabetic retinopathy was associated with higher IGF-I levels at 33 weeks (odds ratio 2.0 [95% confidence interval 1.1-3.6], p=0.02) and higher systolic blood pressure at 8 weeks (1.9 [1.1-3.2], p=0.02) independent of placental GH and HbA(1c) levels. CONCLUSIONS: Pregnancy-induced increase in IGF-I levels is associated with progression of diabetic retinopathy in women with type 1 diabetes.
机译：目的：评估胰岛素样生长因子-I（IGF-I）和胎盘生长激素（GH）对1型糖尿病妇女妊娠期糖尿病性视网膜病变进展的影响。设计：对88名连续1型糖尿病孕妇进行了观察性研究，她们中位数16.5岁（范围1-36），早期妊娠HbA（1c）6.6％（5.2-10.5）。在第8、14、21、27和33周时抽取血液样本以测量IGF-I，胎盘GH和血红蛋白A（1c）（HbA（1c）），并记录血压。在第8和27周进行眼底照相。糖尿病性视网膜病分为五个阶段。进展被定义为糖尿病性视网膜病的至少一个阶段的恶化和/或至少一只眼睛上的黄斑水肿的发展。结果：在整个妊娠过程中胎盘GH和IGF-I水平升高，有22位（25％）发生新发糖尿病或视网膜病变。与没有进展且胎盘水平相似的妇女相比，患有糖尿病性视网膜病变的妇女的急剧增加导致27周时的IGF-I水平升高（p = 0.01），整个妊娠期间的IGF-I水平升高16％（p = 0.02）。整个怀孕期间观察到GH（p = 0.58）和HbA（1c）（p = 0.85）。在多因素logistic回归分析中，糖尿病性视网膜病变的进展与33周时IGF-I水平升高（赔率比2.0 [95％置信区间1.1-3.6]，p = 0.02）和8周时收缩压升高（1.9）有关。 [1.1-3.2]，p = 0.02）与胎盘GH和HbA（1c）水平无关。结论：妊娠诱导的IGF-I水平升高与1型糖尿病女性糖尿病性视网膜病变的进展有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号