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The physiology of gastric emptying

机译：胃排空的生理

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The gastric emptying rate is a carefully regulated process consisting of different mathematically defined phases. The gastric metabolic load, as well as neural regulatory mechanisms and hormonal influences, cooperate in order to achieve a well-balanced emptying of contents from the stomach into the duodenum for absorption in the small intestine, This finely tuned regulation is primarily regulated by the release of gastrointestinal peptide hormones which serve to counteract the emptying process in the fed state and to stimulate sweeping contractions in the fasted state, most likely in order to prepare the stomach for another meal. We have found that the two peptide hormones ghrelin and glucagon-like peptide-1 (GLP-I) have a great impact on the regulation of gastric emptying: ghrelin is a most potent stimulator of gastric contractions and emptying, and GLP-1 profoundly inhibits this emptying process. These data suggest possibilities for governing the rate of gastric emptying as a natural step in achieving metabolic balance and control.
机译：胃排空速率是经过仔细调节的过程，由不同的数学定义阶段组成。胃的新陈代谢负荷以及神经调节机制和激素影响共同作用，以实现从胃到十二指肠的内容物均衡排空，以便在小肠中吸收。这种微调的调节主要由释放调节胃肠肽激素的一种，可用来抵消进食状态下的排空过程，并在禁食状态下刺激大范围收缩，这很可能是为了使胃为另一餐做准备。我们发现，两种肽激素ghrelin和胰高血糖素样肽-1（GLP-1）对胃排空的调节有很大影响：ghrelin是最有效的胃收缩和排空刺激物，而GLP-1可以强烈抑制此清空过程。这些数据表明控制胃排空速率的可能性是实现代谢平衡和控制的自然步骤。

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