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The use of antidepressant medication in pregnancy

机译：孕妇使用抗抑郁药

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The use of antidepressant medications during pregnancy has stimulated much professional and public debate. As a consequence, considerable data on the reproductive safety of antidepressants has been generated that exceeds the available information for most, if not all, other classes of medications that may be used in the perinatal period. Despite progress to date, definitive conclusions are limited by the methodological issues inherent to clinical research involving illness versus treatment effects in pregnancy. A notable shortcoming is the limited discussion of statistically significant (a mathematical determination) versus clinically significant (incorporation of incidence and effect sizes into practical relevance). Research emphasises completing an individualised 'risk-benefit' assessment, which is a laudable goal but falls short in providing succinct practical guidelines that includes the key educational points for patients. In this chapter, we focus on areas in which the preponderance of data are consistent, and there is concordance with the preclinical literature to generate a practical approach for antidepressant use in pregnancy.
机译：怀孕期间使用抗抑郁药引起了很多专业人士和公众的争论。结果，已经产生了有关抗抑郁药生殖安全性的大量数据，这些数据超过了围产期可能使用的大多数（如果不是全部）其他类别药物的可用信息。尽管迄今取得了进展，但明确的结论仍受临床研究中固有的方法论问题的限制，这些问题涉及怀孕对疾病和治疗的影响。一个明显的缺点是关于统计学意义（数学上的确定）与临床意义（将发生率和效应大小纳入实际相关性）的有限讨论。研究强调要完成个性化的“风险效益”评估，这是一个值得称赞的目标，但在提供简洁实用的指南（包括针对患者的关键教育要点）方面却不足。在本章中，我们重点关注数据优势一致的领域，并且与临床前文献保持一致，从而为孕妇使用抗抑郁药提供了一种实用的方法。

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